Nickel

HCID 178781406CAS 21595-53-9

기본 정보

표준 SMILES
[Ni]
InChIKey
PXHVJJICTQNCMI-UHFFFAOYSA-N
분자식
Ni
평균 분자량
58.693 g/mol

개요

Nickel is a very abundant natural element. Pure nickel is a hard, silvery-white metal. Nickel can be combined with other metals, such as iron, copper, chromium, and zinc, to form alloys. These alloys are used to make coins, jewelry, and items such as valves and heat exchangers. Most nickel is used to make stainless steel. Nickel can combine with other elements such as chlorine, sulfur, and oxygen to form nickel compounds. Many nickel compounds dissolve fairly easy in water and have a green color. Nickel compounds are used for nickel plating, to color ceramics, to make some batteries, and as substances known as catalysts that increase the rate of chemical reactions. Nickel is found in all soil and is emitted from volcanoes. Nickel is also found in meteorites and on the ocean floor. Nickel and its compounds have no characteristic odor or taste.

이름 및 식별자

우선 이름
Nickel
IUPAC
nickel
영어명
nickel
분자식
Ni
분자량
58.69

이름 및 동의어

NICKEL7440-02-0Metallic nickelFibrexNickel particlesFibrex PNiccolum metallicumNickel 200Nickel 201Nickel 205Nickel 207Nickel 270
이름 더 보기
Alcan 756NINi 4303TNi 0901-SRCH 55/5NI 0901-S (harshaw)Ni 270CI 77775

데이터베이스 식별자

CAS
21595-53-9
ChEBI
CHEBI:28112
UNII
7OV03QG267、NUZ5T2QN2V
EC Number
231-111-4、445-070-7、935-135-2
Nikkaji
J154.814J、J263.657C、J3.729J

물성

구조 계산 물성

극성 표면적
0 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
0
회전 가능 결합 수
0
무거운 원자 수
1

실험 및 물리화학적 성질

Chemical Classes · 5건

Hazardous Air Pollutants (HAPs)

Urban Hazardous Air Pollutants (HAPs) - EPA specified greatest potential health threat in urban areas

Metals -> Nickel Compounds, Inorganic

Carcinogens

Trace element

CosmeticsCosmetics ingredient -> Fragrance
SpringerMaterials Propertiesthermal expansion coefficient
OdorOdorless
Food AdditivesPROCESSING AID -> FDA Substance added to food
Density · 6건

8.9 (Metal) (NIOSH, 2024) - Denser than water; will sink

8.908 (NTP, 1992) - Denser than water; will sink

8.908

8.9 g/cm³

8.90 (metal)

8.90 (metal)

물리화학적 성질

물리적 상태
2 %, · 스펀지, 철 2%, 크롬 2.5%
색상
짙은 회색

안전 및 규제

GHS 분류

GHS Classification · 6건

Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

P203, P260, P261, P264, P270, P272, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

유해성 정보

Regulatory Information · 6건

Chemical: Nickel

Nickel is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Nickel are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15544

Restricted substance: Nickel

Status: Active Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/5124

Nickel: HSNO Approval: HSR003031 Approved with controls

Other Safety InformationIMAP assessments - Nickel: Human health tier II assessment
DOT LabelSpontaneously Combustible
Fire Hazards · 3건

Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:

· Flammable/combustible material.

Flammable as dust. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

Health Hazards · 3건

Excerpt from NIOSH Pocket Guide for Nickel metal and other compounds (as Ni):

Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:

· Fire will produce irritating, corrosive and/or toxic gases.

Hazards Summary · 3건

Nickel is a very abundant natural element. Pure nickel is a hard, silvery-white metal. Nickel can be combined with other metals, such as iron, copper, chromium, and zinc, to form alloys. These alloys are used to make coins, jewelry, and items such as valves and heat exchangers. Most nickel is used to make stainless steel. Nickel can combine with other elements such as chlorine, sulfur, and oxygen to form nickel compounds. Many nickel compounds dissolve fairly easy in water and have a green color. Nickel compounds are used for nickel plating, to color ceramics, to make some batteries, and as substances known as catalysts that increase the rate of chemical reactions. Nickel is found in all soil and is emitted from volcanoes. Nickel is also found in meteorites and on the ocean floor. Nickel and its compounds have no characteristic odor or taste.

Nickel occurs naturally in the environment at low levels. Nickel is an essential element in some animal species, and it has been suggested it may be essential for human nutrition. Nickel dermatitis, consisting of itching of the fingers, hands, and forearms, is the most common effect in humans from chronic (long-term) skin contact with nickel. Respiratory effects have also been reported in humans from inhalation exposure to nickel. Human and animal studies have reported an increased risk of lung and nasal cancers from exposure to nickel refinery dusts and nickel subsulfide. Animal studies of soluble nickel compounds (i.e., nickel carbonyl) have reported lung tumors. EPA has classified nickel refinery dust and nickel subsulfide as Group A, human carcinogens, and nickel carbonyl as a Group B2, probable human carcinogen.

Nickel carbonyl can cause acute pneumonitis. [Hendrick, p. 180] Asthma: metal plating; [Malo] Most OA cases caused by nickel were single case reports. [Asthma in the Workplace, p. 297] Allergic contact dermatitis: electronics workers, hairdressers, housekeeping personnel, textile workers, and machinists; [Marks] About one half of nickel produced is used in stainless steel alloys. Sulfur-rich stainless steels are more likely to react with sweat, be absorbed in the skin, and cause sensitization. The prevalence of nickel skin allergy is higher in women (up to 17%) than in men (up to 3%) because of greater exposure to ear piercing and cheap jewelry. Allergic contact dermatitis (ACD) has been reported in electroplaters, battery workers, electronics workers, machinists, hairdressers, mechanics, and construction workers. ACD has also been reported in a bank clerk, a bartender, an engraver, a potter, and in tailors, offset printers, butchers, and musicians. The dimethylglyoxime test (Fisher's test) can detect nickel release from tools and jewelry. [Kanerva, p. 485-92] Nickel causes contact urticaria; [Kanerva, p. 219] In high-dose animal studies, nickel and nickel carbonyl cause birth defects. [Frazier] The relevance of a positive patch test to occupational contact dermatitis (OCD) is difficult to evaluate in most cases. Nickel is not considered relevant in about 64% of OCD cases. [See Reference #1] Nickel is hepatotoxic. [Nordberg, p. 1099] Elemental nickel and nickel alloys are possible human carcinogens; nickel compounds are known human carcinogens. The highest risks were found in calcining workers heavily exposed to nickel oxides and sulfides. Soluble nickel (nickel sulfate) was associated with increased risks in hydrometallurgy workers. [IARC] Nickel elemental = A5; Soluble inorganic compounds = A4; Insoluble inorganic compounds = A1; Nickel subsulfide = A1; Increased risk of lung and nasal sinus cancer in nickel refinery workers exposed to >1 mg Ni/m3 (soluble nickel) and >10 mg/m3 (insoluble nickel); [ACGIH] Metallic nickel is listed as anticipated and nickel compounds are listed as known human carcinogens. Several cohort studies of workers exposed to various nickel compounds showed an elevated risk of death from lung cancer and nasal cancer. Although the precise nickel compound responsible for the carcinogenic effects in humans is not always clear, studies indicate that nickel sulfate and combinations of nickel sulfides and oxides encountered in nickel refining industries cause cancer in humans. [NTP] See Nickel carbonyl.

안전 및 보호

Fire Fighting · 2건

Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:

Use dry sand, dry powder. NO carbon dioxide. NO water.

First Aid Measures · 4건

Fresh air, rest.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

Accidental Release Measures · 2건

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 4건

Excerpt from NIOSH Pocket Guide for Nickel metal and other compounds (as Ni):

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

Safe StorageStore only in original packaging. Cool. Well closed. Separated from strong oxidants and acids. Store in an area without drain or sewer access.
Exposure Control and Personal Protection · 2건

· Wear positive pressure self-contained breathing apparatus (SCBA).

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

독성 정보

Toxicological InformationCDC-ATSDR Toxicological Profile
Cancer Sites[lung and nasal cancer]
Target Organs · 2건

Cancer, Dermal (Skin), Developmental (effects while organs are developing), Immunological (Immune System), Respiratory (From the Nose to the Lungs)

Nasal cavities, lungs, skin

Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Exposure Routes · 2건

The substance can be absorbed into the body by inhalation of dust.

inhalation, ingestion, skin and/or eye contact

Toxicity Summary · 1건

Nickel is a ubiquitous trace metal and occurs in soil, water, air and the biosphere. Nickel ore deposits are accumulations of nickel sulfide minerals (mostly pentlandite) and laterites. Most nickel is used for production of stainless steel and other nickel alloys with high corrosion and temperature resistance. Nickel levels in terrestrial and aquatic organisms can vary over several orders of magnitude. Dermal exposure in the general environment is important for the induction and maintenance of contact hypersensitivity caused by daily contact with nickel plated objects or nickel containing alloys (e.g. jewellery, coins or clips). Iatrogenic exposure to nickel results from implants and prostheses made from nickel containing alloys, from iv or dialysis fluids and from radiographic contrast media. In the working environment, airborne nickel concentrations can vary from a few microgram/cu m to a few mg/cu m, depending upon the process involved and the nickel content of the material being handled. Workers are exposed to nickel containing dusts and fumes during welding, plating, grinding, mining, nickel refining, and in steel plants. Dermal exposure to nickel may occur in a wide range of jobs, either by direct exposure, dissolved nickel in refining, electroplating and electroforming industries or by handling nickel containing materials. Nickel can be absorbed in human beings and animals via inhalation or ingestion or percutaneously. Respiratory absorption with secondary gastrointestinal absorption (insoluble and soluble) is a major route of entry during occupational exposure. Percutaneous absorption is negligible, quantatively, but is important in the pathogenesis of contact hypersensitivity. Nickel is transported in the blood, principally bound to albumin. Gastrointestinal absorption of nickel is variable and depends on the composition of the diet. All body secretions are potential routes of excretion including the urine, bile, sweat, tears, milk and mucociliary fluid. Non-absorbed nicke is eliminated in the feces. Data on nickel excretion suggest a two compartment model. Nickel concentration in the serum and urine of healthy non-occupationally exposed adults are 0.2 ug/l (range: 0.05-1.1 ug/l) and 1.5 ug creatinine (range: 0.5-4.0 mg/g creatinine, respectively. The body burden of nickel in non-exposed 70 kg adult is 0.5 ug. Nickel is essential for the catalytic activity of some plant and bacterial enzymes. Slow weight gain, anemia and decreased viability has been described in some animal species after dietary deprivation of nickel. Contact allergy to nickel is very common in human beings; experimental sensitization in animals is only successful under special conditions. Longterm inhalation exposure to metallic nickel caused mucosal damage and inflammatory reaction, sometimes accompanied by slight fibrosis, was observed in rabbits after high level exposure to nickel graphite dust. Metallic nickel induced local mesenchymal tumors in a variety of experimental animals after im, sc, intraosseous, intrarenal, intra-articular, pleural, intraocular, intratesticular or intra-adipose administrtation. Metallic nickel has been tested for carcinogenicity by parenteral routes of administration, local tumors were noted. In studies using repeated intratracheal instillation, nickel powder caused respiratory tumors. Chronic effects such as rhinitis, sinusitis, nasal septal perforations and asthma have been reported in nickel refinery and nickel plating workers. Some researchers reported pulmonary changes with fibrosis in workers handling nickel dust. Orsal nickel intake may aggravate vesicular hand eczema. Prostheses or other surgical implants make with nickel containing alloys have been reported to cause nickel sensitization. Cancer rates have generally been close to normal in stainless steel welding and nickel using industries, with the exception of those involving exposure to chromium, particularly electroplating. Nickel/cadmium battery workers exposed to high levels of both nickel and cadmium may have resulted in a slightly increased risk of lung cancer. Excesses of various cancers other than lung and nasal cancers such as renal, gastric or prostatic have occasionally been reported in nickel workers, but none have been found consistently. No increased cancer risk has been demonstrated in workers exposed exclusively to metallic nickel. The combined data on nickel alloy workers and gasseous diffusion workers, all of whom were exposed to average concentrations of the order of 0.5 mg nickel/cu m show no excess risk, though the total number of lung cancers in these cohorts was to small to exclude a small increase in risk at this level.

규제 정보

FDA RequirementsSubstance added directly to human food affirmed as generally recognized as safe (GRAS).
Atmospheric Standards · 1건

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Nickel is included on this list.

CERCLA Reportable Quantities · 1건

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.5 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Clean Water Act RequirementsToxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Nickel and compounds/
State Drinking Water Standards · 5건

(CA) CALIFORNIA 100 ug/L

(CT) CONNECTICUT 100 ug/L

(DE) DELEWARE 100 ug/L

(FL) FLORIDA 100 ug/L

(WI) WISCONSIN 100 ug/L

State Drinking Water Guidelines · 4건

(AZ) ARIZONA 150 ug/L

(MA) MASSACHUSETTS 100 ug/L

(ME) MAINE 140 ug/L

(MN) MINNESOTA 100 ug/L

화학 및 산업

약리 정보

Mechanism of Action · 1건

Nickel is hepatotoxic in animals and has been shown to effect renal function in man. It binds to the anionic glycosaminoglycan sites of the glomerular basement membrane. Ionic blocking of these sites leads to the loss of selectivity in the filtration of albumin and may explain the proteinuria associated with nickel exposure.

Biological Half-Life · 2건

Whole body: 28 hours; [TDR, p. 929]

On the basis of nickel values in air, plasma and urine in four nickel platers during one working week ... /the investigators/, assuming a one-compartment model, computed the biological half-life for nickel in plasma to range from 20 to 34 hr and in urine from 17 to 39 hr.

FDA Pharmacological Classification · 6건

7OV03QG267

NICKEL

Established Pharmacologic Class [EPC] - Standardized Chemical Allergen

Physiologic Effects [PE] - Increased Histamine Release

Physiologic Effects [PE] - Cell-mediated Immunity

Chemical Structure [CS] - Allergens

MeSH Pharmacological ClassificationA group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Absorption, Distribution and Excretion · 1건

THIRTY-FIVE LUNG PAIRS OBTAINED DURING AUTOPSY FROM RANDOMLY SELECTED PATIENTS WERE INVESTIGATED BY PARTICLE INDUCED X-RAY EMISSION FOR OVERALL & REGIONAL ELEMENTAL CONTENT DETERMINATION. NICKEL DISTRIBUTION SEEMS TO BE RELATED TO AIR POLLUTION PECULIAR TO /BELGIUM/.

용도 및 제조

Uses · 6건

Nickel is used for nickel alloys, electroplating, batteries, coins, industrial plumbing, spark plugs, machinery parts, stainless-steel, nickel-chrome resistance wires, and catalysts. Nickel carbonyl has severely limited use in nickel refining.

In the past, nickel refinery workers had an increased risk for lung cancer because of significant nickel exposure. Workers are exposed to nickel in the production of nickel carbonyl from the Mond process; [LaDou, p. 480] Skin exposure to nickel is very common from electroplated or alloyed metals including: costume jewelry, clothing zippers and snaps, coins, keys, tools, utensils, instruments, metal furniture, batteries, machinery parts, and metalworking fluids. [Marks, p. 109] Nickel is also used as a catalyst; it is released in emissions from burning fossil fuels. [ATSDR ToxProfiles]

Steel Producing [Category: Industry]

Ceramics making [Category: Hobbies]

Nickel plating; for various alloys such as new silver, Chinese silver, German silver; for coins, electrotypes, lightning rod tips, electrical contacts and electrodes, spark plugs, machinery parts; catalyst for hydrogenation of org substances; in mfr of monel metal, stainless steels, and nickel chrome resistance wire; in alloys for electronic and space applications

IT IS EXTENSIVELY USED FOR MAKING STAINLESS STEEL & OTHER CORROSION RESISTANT ALLOYS ... TUBING MADE OF COPPER NICKEL ALLOY ... USED IN MAKING DESALINATION PLANTS ... IN MAKING NICKEL STEEL ARMOR PLATE & BURGLAR PROOF VAULTS ... NICKEL ADDED TO GLASS GIVES GREEN COLOR.

U.S. Exports · 4건

(1978) 3.30X10+10 G

(1982) 5.18X10+10 G

(1986) 2.72X10+9 g

(1997) 17,600 tons metric (ore); 147,000 metric tons (primary); 11,000 metric tons (secondary).

U.S. Imports · 5건

(1978) 2.13X10+11 G

(1982) 1.18X10+11 G

(1986) 1.27X10+11 g

(1998, estimated): 1,420 metric tons (ore); 155,000 metric tons (primary); 9,780 metric tons (secondary)

Import sources (1994-97): Canada, 37%; Norway, 15%; Russia, 14%; Australia, 10%; and other, 24%.

U.S. Production · 6건

2023: 250,000,000 - <400,000,000 lb

(1978) 3.39X10+10 G

(1982) 4.08X10+10 G

(1986) 3.84X10+10 g

(1992) 1.27X10+6 metric tons

(1997) 16,000 tons

Consumption Patterns · 5건

FERROUS ALLOYS, 44%; OTHER ALLOYS, 32%; ELECTROPLATING, 20%; OTHER, 4% (1982)

Transportation, 25%, chemical industry, 15%; electrical equipment, 9%; construction, 9%; fabricated metal products, 9%; petroleum, 8%; household appliances, 7%; machinery, 7%; and other, 11% (1986)

Stainless steel producers accounted for 40% of primary nickel demand in the United States and more than 60% of primary demand in the world.

Approximately 44% of the primary nickel consumed went into stainless and alloy production, 38% into nonferrous alloys and super alloys, 14% into electroplating, and 4% into other uses.

For more Consumption Patterns (Complete) data for NICKEL, ELEMENTAL (7 total), please visit the HSDB record page.

Consumer UsesAnti-adhesive/cohesive

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