| GHS 분류 | DangerH314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H330: Fatal if inhaled [Danger Acute toxicity, inhalation]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]P260, P264, P271, P273, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.1% (1 of 725) of reports. |
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| Hazards Identification | Toxic/poison by inhalation (TIH/PIH) |
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| 규제 정보 | Chemical: BromineBromine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Bromine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 21-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15150Status: Active Update: 28-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23370Bromine: HSNO Approval: HSR002917 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| 기타 안전 정보 | IMAP assessments - Bromine: Environment tier I assessmentIMAP assessments - Bromine: Human health tier I assessment |
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| 운송 라벨(DOT) | Corrosive Poison Inhalation Hazard |
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| 화재 위험 | Will cause ignition of organic materials spontaneous ignition possible when combined with potassium, phosphorus and tin and a wide variety of other chemicals. It reacts explosively with acetylene, acrylonitrile, ammonia, dimethyl formamide, ethyl phosphine, hydrogen, isobutyrophenone, nickel carbonyl, nitrogen triiodide, ozone, oxygen difluoride, phosphorus, potassium, silver azide, sodium and sodium carbide. When heated it emits highly toxic fumes and will react with water or steam to product toxic and corrosive fumes. Bromine is incompatible with a wide variety of materials including alkali hydroxidesarsenitesferrous, mercurous saltshypophosphites and other oxidizable substances. Vaporizes rapidly at room temperature. (EPA, 1998)Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Corrosives in contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion or sodium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2024)· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.· Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.).· Corrosives in contact with metals may evolve flammable hydrogen gas.· Containers may explode when heated.· For electric vehicles or equipment, GUIDE 147 (lithium ion or sodium ion batteries) or GUIDE 138 (sodium batteries) should also be consulted.Not combustible but enhances combustion of other substances. Many reactions may cause fire or explosion. Heating will cause rise in pressure with risk of bursting. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion. See Chemical Dangers. |
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| 건강 유해성 | Inhalation exposure to 11-23 mg/m3 produces severe choking. 30-60 mg/m3 is extremely dangerous. 200 mg/m3 is fatal in a short time. Vapors can cause acute as well as chronic poisoning. It has cumulative properties. It is irritating to the eyes and respiratory tract. Poisoning is due to the corrosive action on the gastrointestinal tract. Nervous, circulatory and renal disturbances occur after ingestion. Ingestion of liquid can cause death due to circulatory collapse and asphyxiation from swelling of the respiratory tract. The lowest oral lethal dose reported for humans is 14 mg/kg. The lowest lethal inhalation concentration reported for humans is 1000 ppm. (EPA, 1998)Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024)· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death.· Contact with molten substance may cause severe burns to skin and eyes.· Avoid any skin contact.· Fire may produce irritating, corrosive and/or toxic gases.· Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. |
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| 유해성 요약 | Liquid causes second or third degree burns after short contact[CHRIS] Highly corrosive to skin[Quick CPC] Listed as one of major irritant airborne toxicants[LaDou, p. 563] A lachrymator[HSDB] Causes lachrymationA corrosive substance that can cause pulmonary edema[ICSC] Bromide compounds have been used since the 19th century as sedatives and anticonvulsants. Because of the risk of chronic bromide poisoning (bromism), bromide salts were removed from most pharmaceuticals in the US by 1978. The findings of bromism include neuropsychiatric symptoms and acne. [Ford, p. 559] The bromide ion has a long half-life so that bioaccumulation and delayed toxicity may be observed. [Goldfrank, p. 1066] When spilled in water Bromine trifluoride and Bromine pentafluoride can release HF and Bromine. [ERG 2016] See the Process, Toxic Gas from Spilling Chemical in Water. |
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| 운송 번호 및 가이드(DOT) | 1744 154 |
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| 반응성 그룹 | Oxidizing Agents, StrongHalogenating AgentsWater and Aqueous Solutions |
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| EC 분류 | Symbol: T+, C, NR: 26-35-50S: (1/2)-7/9-26-45-61 |
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| UN 분류 | UN Hazard Class: 8UN Subsidiary Risks: 6.1UN Pack Group: I |
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| Special Reports | European Chemicals BureauIUCLID Dataset, Bromine (CAS # 7726-95-6)IPCS INCHEMPoisons Information Monographs, Bromine (PIM 080)Dillon HKMethods Development for Sampling and Analysis of Chlorine, Chlorine dioxide, Bromine, and IodineNTIS Report PB83-246363 (SORI-EAS-82-828): 30 (1983). Sampling & analysis methods developed for the detection of toxic oxidants such as bromine, chlorine, chlorine dioxide & iodine in air.NTIS Report PB83-244988 (SORI-EAS-82-672): 50 (1983). Sampling & analysis methods developed for the detection of bromine in workplace air.For more Special Reports (Complete) data for BROMINE (6 total), please visit the HSDB record page. |
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| 소화 | Wear positive pressure breathing apparatus and special protective clothing. Move containers from fire area. Cool containers that are exposed to flames with water.Nonflammable, but a strong oxidizer. Extinguish with dry chemical, carbon dioxide, water spray, fog or foam. (EPA, 1998)Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:SMALL FIRE: Dry chemical, CO2 or water spray.LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water. |
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| 응급 조치 | Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Put clothes in sealable container. Refer immediately for medical attention.Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. |
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| 누출 비상 조치 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Ventilate closed spaces before entering, but only if properly trained and equipped.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.· Stop leak if you can do it without risk.· Prevent entry into waterways, sewers, basements or confined areas.· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.· DO NOT GET WATER INSIDE CONTAINERS. |
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| 응급 처치 | Warning: Effects may be delayed for several hours. Caution is advised.Signs and Symptoms of Acute Bromine Exposure: Signs and symptoms of acute exposure to bromine may include hypotension (low blood pressure), tachycardia (rapid heart rate), cyanosis (blue tint to the skin and mucous membranes), and circulatory collapse. Neurological effects may include headache, dizziness, delirium, stupor, and shock. Gastrointestinal effects may include vomiting (vomitus may be blue), diarrhea, abdominal pain, and bloody stools. Nephritis with oliguria (scanty urination) and anuria (absence of urine formation) has been reported. Bromine is irritating to the skin, eyes, and mucous membranesbrown discoloration of the mucous membranes, lips, and tongue may be observed. Lacrimation (tearing), photophobia (heightened sensitivity to light), nosebleeds, coughing, asphyxiation, and pulmonary edema may also occur. A burning pain in the mouth and esophagus generally follows ingestion.Emergency Life-Support Procedures: Acute exposure to bromine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying and supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.Inhalation Exposure:1. Move victims to fresh air. Emergency personnel should avoid self-exposure to bromine.2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.4. Transport to a health care facility.Dermal/Eye Exposure:1. Remove victims from exposure. Emergency personnel should avoid self- exposure to bromine.3. Remove contaminated clothing as soon as possible.4. If eye exposure has occurred, eyes must be flushed IMMEDIATELY with lukewarm water for at least 15 minutes.5. IMMEDIATELY wash exposed skin areas THOROUGHLY with soap and water.6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.7. Transport to a health care facility.Ingestion Exposure:1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.2. DO NOT induce vomiting or attempt to neutralize!Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. (ERG, 2024)General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. |
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| 안전 보관 | Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. Cool. Dry. Well closed. Keep in a well-ventilated room. Store only in original container. Store in an area without drain or sewer access. |
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| Firefighting Hazards | Special hazards arising from the substance or mixture: Hydrogen bromide gas. Container explosion may occur under fire conditions. |
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| 노출 관리 및 개인 보호 | · Wear positive pressure self-contained breathing apparatus (SCBA).· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016]. |
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| 소화 절차 | If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use water spray to knock-down vapors.Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.May intensify fireoxidizer.Fire Fighting Procedures: Use water spray to keep fire-exposed containers cool. Use appropriate extinguishing agents on nearby combustible fires. |
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| 보관 조건 | Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Do not store in polyethylene containers. Handle and open container with care.Storage Recommendations: Store in cool, dry, well-venilated location. Separate from oxidizing materials. |
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| 정리 방법 | 1) VENTILATE AREA OF SPILL OR LEAK. 2) COLLECT FOR RECLAMATION OR ABSORB IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL OR POUR SODIUM THIOSULFATE OR LIME WATER OVER SMALL SPILLS.Soln or slurries of 10-50% potassium carbonate, 10-13% sodium carbonate, & 5-10% sodium bicarbonate or saturated "hypo" soln (prepared by dissolving 4 kg of technical-grade sodium thiosulfate in 9.5 l of water & adding 113 g of soda ash) are preferred neutralizing agents for liquid bromine spills.A 5% lime slurry or 5% sodium hydroxide soln may be used, but heats of reaction are higher for these reagents. Ammonia soln should not be applied to liquid spills because of the high heat of reaction & nitrogen evolution. Anhydrous ammonia gas is useful for neutralization of bromine fumes.Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.Spill or Leak Procedures: Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors and protect personnel. Use soda ash to neutralize liquid. Control runoff and isolate discharged material for proper disposal. |
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| 비화재 누출 대응 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024) |
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| 처리 방법 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.Waste treatment methods. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging: Dispose of as unused product.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal. |
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| Treatment | Bromine should be washed with water from any areas of dermal or ocular contact. If inhaled, treatment is mainly symptomatic and may include maintaining an adequate airway, administering oxygen, antibronchospasm therapy, and/or antibiotics. (L626) |
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| 표적 장기 | respiratory system, eyes, central nervous system, skin |
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| 건강 영향 | Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627) |
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| 생태독성 수치 | LC50Species: Daphnia magna (Water flea) age < or = 24 hrConditions: freshwater, static, 22 °C, pH 8.0 (7.4-9.4), hardness 173 mg/L CaCO3, dissolved oxygen >60%Concentration: 1500 ug/L for 24 hr (95% confidence interval: 1000-2200 ug/L)Concentration: 1000 ug/L for 48 hr (95% confidence interval: 460-2200 ug/L)Species: Lepomis macrochirus (Bluegill)Conditions: freshwater, staticConcentration: 0.52 ppm for 24 hr (95% confidence interval: 0.38-0.83 ppm)Species: Oncorhynchus mykiss (Rainbow trout)Concentration: 0.31 ppm for 24 hr (95% confidence interval: 0.28-0.35 ppm) |
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| 환경 거동 | TERRESTRIAL FATE: Volatilization of bromine from moist soil surfaces is expected to be an important fate process(SRC) given a estimated Henry's Law constant of 1.32X10-3 atm-cu m/mole(1). Bromine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 212 mm Hg at 25 °C(2). Bromine is reportedly vaporized rapidly at room temperature(3). Bromine will slowly be reduced to bromide by natural oxidizable materials in water and soil(4).AQUATIC FATE: Volatilization of bromine from water surfaces is expected(1) based upon a Henry's Law constant of 1.32X10-3 atm-cu m/mole(2). Using this Henry's Law constant and an estimation method(1), volatilization half-lives for a model river and model lake are 4.5 hours and 5 days, respectively(SRC). When bromine dissolves in water, it partially disproportionates into HOBr (hypobromous acid) and HBr(3). Above pH 3, the fraction present as Br2 decreases and HOBr is formed(4)between pH 6 and pH 8, most of the bromine is present as HOBr(4). Bromine will slowly be reduced to bromide by natural oxidizable materials in water and soil(4). Bromine absorbs at wavelengths >290 nm(5) and, therefore, may be susceptible to direct photolysis on water surfaces exposed to sunlight(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromine, which has a vapor pressure of 212 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase bromine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 8.6 hours(SRC), calculated from its rate constant of 4.5X10-11 cu cm/molecule-sec at 25 °C(3). The reaction of bromine with photochemically-produced hydroxyl radicals yields the bromide radical and HOBr(3). Bromine absorbs at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). |
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| 유해 작용 | Neurotoxin - Other CNS neurotoxinDermatotoxin - Skin burns.Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. |
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| 노출 경로 | Serious local effects by all routes of exposure.inhalation, ingestion, skin and/or eye contactOral (L626)inhalation (L626)dermal (L626) |
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| 독성 요약 | IDENTIFICATION AND USE: Bromine is a dark reddish-brown, volatile, mobile diatomic liquidvaporizes at room temperature. Pure bromine is used in the synthesis of a variety of bromine containing substances. Other uses for bromine include flame retardants, cleaning agents, dyestuffs, photography, water sanitation, pharmaceuticals, bleaching fibers and silk. Bromine is registered for use in water filters to purify drinking water aboard US Naval ships and offshore oil well platforms. It is also used as a general disinfectant and sanitizer in indoor, non-food contact areas such as commercial establishments, hospitals and households, to control bacteria and fungi. HUMAN EXPOSURE AND TOXICITY: Inhalation of the irritant bromine vapors or direct contact with the liquid or vapor with skin and mucous membranes will produce direct tissue injury. Injury may occur at various levels of the respiratory tract depending upon the concentration of bromine and the duration of exposure. Pure bromine liquid or vapor is extremely irritating to the skin. Unlike other chemical agents, there is no immediate visible skin reaction after contact. The delay before initial signs or injury become apparent often results in more extreme damage. The most common local effects are blister formation, brownish discoloration of the skin and slow healing ulcers. Exposure to low concentrations produces lacrimation, rhinorrhea, eye irritation, coughing, dyspnea, choking, wheezing, epistaxis and headache. A brownish discoloration of the tongue and buccal mucosa may result and be accompanied by a characteristic breath odor. Inflammatory lesions of the upper airway, photophobia and blepharospasm are noted at higher levels. Upper and lower respiratory tract: delayed or immediate bronchoconstriction and the development of laryngeal spasm, glottal edema and asthma. With increased parenchymal penetration, there may be associated peribronchiolar abscesses, pulmonary infiltrates consistent with chemical pneumonitisBromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543) |
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| 생태독성 발췌 | /AQUATIC SPECIES/ Zygotes and young embryos derived from Fucus vesiculosus /bladderwack (seaweed)/ collected in the achipelgo of Stockholm (Sweden) in 1990, growing at a salinity of 6 to 7 S /salinity/, were cultured under different salinity conditions and in media of different bromine concentrations. Optimum salinity was 10 to 12 S for germination (rhizoid initiation) while apical hair formation showed a broader tolerance curve with an optimum at 8 to 14 S. Bromide caused inhibition of early development of F. vesiculosus. At 6 salinity a 50% reduction in germination took place at 10.0 mM Br and at 1.25 mM Br only 4.7% of the embryos developed apical hairs, as compared to 32.7% in the control. Bromine toxicity decreased at higher salinities. The results indicate that F. vesiculosus in the Baltic Sea has diverged from its Altantic progenitors and to some extent acclimated to low salinity. Still, the salinity in the normal environment of the tested population is lower than optimum, leading to a lower degree of germination./PLANTS/ Immediate and delayed (24 hr) effects of a 20 min exposure of cowpea primary leaf tissue to 1, 3, or 5 ppm bromine gas was studied. The formation of circular, adaxial and abaxial surface lesions and leaf compression were the most visible changes. At 1 ppm cellular changes such as adaxial depression and anticlinal cell wall interdigitation were reversed when exposed plants were returned to normal environment. At 5 ppm the entire population immediately became irreversibly necrotic./PLANTS/ Bromine releases as a consequence of ... production activities has had serious effects upon vegetation in the locale. The first noted manifestation of a problem was damage to coniferous trees near the bromine plants. Needle tip necrosis after 13 to 14 month and 1 to 2 month exposure times was very evident within a 3 mile radius of all bromine facilities sampled. At further distances of 3.5 to 12 miles, tip damage was sporadic, varying from tree to tree, and not evident on 1 to 2 month-exposure needles. The foliage burn and death of trees within 0.5 to 1 mile was extreme. Conifers were decidedly more susceptible to the bromine emissions than were broadleaf trees, shrubs, and grasses. Chlorophyll (a and b) levels were greatly reduced in the conifer trees surrounding the bromine plants. This was taken as a strong indicator of extreme air pollution problems because chlorophyll does not reflect environmental problems until they become overwhelming. |
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| Signs and Symptoms | Cough. Sore throat. Shortness of breath. Wheezing. Laboured breathing. Symptoms may be delayed.Redness. Burning sensation. Pain. Serious skin burns.Watering of the eyes. Redness. Blurred vision. Pain. Burns.Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal pain. Shock or collapse.dizziness, headachelacrimation (discharge of tears), epistaxis (nosebleed)cough, feeling of oppression, pulmonary edema, pneumonitisabdominal pain, diarrheameasle-like eruptionseye, skin burnsBromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. (L626, L627) |
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| ICSC Environmental Data | The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. |
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| Medical Surveillance | Laboratory criteria for diagnosis: Biologic: No specific test for bromine is availablehowever, detection of elevated bromide levels in serum (reference level is 50-100 mg/L) might indicate that an exposure has occurred. |
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| FIFRA 요건 | The food additives, bromide ion and residual bromine, may be present in water, potable in accordance with the following conditions: (1) The food additives are present as a result of treating water aboard ships with a polybrominated ion-exchange resin (as a source of bromine) under the supervision of trained personnel. (2) Residual bromine levels are controlled to not exceed 1.0 part per million (ppm) in the final treated water. Control is effected using calibrated recirculating or proportioning bromine feeder equipment and periodic checks of residual bromine using a bromine test kit. To assure safe use of the additives, the label and labeling of the disinfectant formulation containing the food additives shall conform to the label and labeling registered by the U.S. Environmental Protection Agency. (3) No tolerance is established for bromide ion levels. /Bromide ion and residual bromine/A tolerance exemption for use of residual bromine in potable water has been granted. In the 1993 Bromine RED, the Agency indicated the need for confirmatory data (i.e., 171-4(f) magnitude of residue in potable water) to alleviate potential concerns about the conversion of bromine into bromate, which is a known carcinogen. In response to the data call-in, two studies were conducted to determine the magnitude of bromate residues in potable water. At the pH level expected for drinking water disinfection on ships/oil platforms, the bromate levels in these studies were non detect. Hence at this time the Agency does not have concerns for the use of bromine as a drinking water disinfectant (on ships/oil platforms). The Agency has evaluated all current registered uses of bromine and has determined based on available data, that there is a reasonable certainty that no harm to any population subgroup will result from exposure to bromine. Therefore, no mitigation measures are needed, and the current tolerances established at 40 CFR180.519 for residues of residual bromine in potable water are now considered reassessed under section 408(q) of the FFDCA.Based on the reviews of the generic data for the active ingredient bromine, the Agency has sufficient information on the health effects of bromine and on its potential for causing adverse effects to the environment. The Agency has determined that bromine products, labled and used as specified in this Reregistration Eligibility Decision, will not pose unreasonable risks or adverse effects to humans or the environment, and therefore, the Agency concludes that products containing bromine for all uses are eligible for reregistration.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Bromine is found on List D. Case No: 4015Pesticide type: Insecticide, fungicide, antimicrobialCase Status: RED Approved 01/94OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.Active ingredient (AI): BromineData Call-in (DCI) Date(s): 11/15/93AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI. |
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| CERCLA 보고 수량 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Bromine is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 lbs. |
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| DHS Chemicals of Interest (COI) | Bromine110000Toxic chemical that can be released at a facility. |
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