| GHS 분류 | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]H312: Harmful in contact with skin [Warning Acute toxicity, dermal]H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H330: Fatal if inhaled [Danger Acute toxicity, inhalation]H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]H340: May cause genetic defects [Danger Germ cell mutagenicity]H350: May cause cancer [Danger Carcinogenicity]H360FD: May damage fertilityMay damage the unborn child [Danger Reproductive toxicity]H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P320, P321, P330, P333+P317, P342+P316, P362+P364, P363, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement) |
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| 규제 정보 | Chemical: Chromic acid (H2CrO4), disodium saltHazard Traits - CarcinogenicityGenotoxicityReproductive ToxicityRespiratory ToxicityAuthoritative List - EC Annex VI CMRs - Cat. 1BEC Annex VI Resp. Sens. - Cat. 1Report - if used as a fragrance or flavor ingredientR - indicates a substance that is the subject of a TSCA section 6 risk management rule.Status: Active Update: 16-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/11312Substance: Sodium chromateEC: 231-889-5Date of inclusion: >18-Jun-2010Reason for inclusion: Carcinogenic (Article 57a)Mutagenic (Article 57b)Toxic for reproduction (Article 57c)Sodium chromate, anhydrous: HSNO Approval: HSR004684 Approved with controls |
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| 기타 안전 정보 | IMAP assessments - Chromates and dichromates (soluble): Human health tier II assessment |
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| 운송 라벨(DOT) | Oxidizer CorrosivePoison |
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| 화재 위험 | Special Hazards of Combustion Products: Toxic chromium oxide fumes may form in fire.Behavior in Fire: May increase intensity of fire when in contact with combustible material (USCG, 1999)Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2024)Not combustible but enhances combustion of other substances. |
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| 건강 유해성 | Inhalation causes irritation and may ulcerate mucous membranescontinued irritation of the nose may lead to perforation of the septum. Ingestion causes severe circulatory collapse and toxic nephritismay be fatal. Contact with eyes causes severe irritation and possible conjunctivitis. Irritates skin and can cause ulcersif skin is broken, prolonged contact may cause "chrome sores" (slow-healing, hard-rimmed ulcers), which leave the area vulnerable to infection as a secondary effect. (USCG, 1999)Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:Highly toxic, may be fatal if inhaled, ingested or absorbed through skin. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024) |
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| 유해성 요약 | A corrosive substance that can cause injury to the skin, eyes, and respiratory tractCan be absorbed through skinMay cause skin sensitization and asthma after prolonged contactMay cause kidney and liver injuryMay cause perforated nasal septum[ICSC] Can cause burnsVery toxic by inhalationMay cause skin and respiratory sensitization after prolonged contact[eChemPortal: ESIS] See Chromium and linked occupational diseases. |
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| FDA 요건 | Sodium chromate is an indirect food additive for use only as a component of adhesives. |
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| 반응성 그룹 | Salts, BasicOxidizing Agents, StrongWater and Aqueous Solutions |
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| EC 분류 | Symbol: T+, NR: 45-46-60-61-21-25-26-34-42/43-48/23-50/53S: 53-45-60-61Note: E, 3 |
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| UN 분류 | UN Hazard Class: 6.1UN Pack Group: II |
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| Special Reports | DHHS/ATSDRToxicological profile for chromium (September 2012).[DHHS/ATSDRToxicological profile for chromium (September 2012)Available from, as of February 8, 2016: ww.atsdr.cdc.gov/toxprofiles/tp7.pdf] |
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| RCRA 요건 | D007A solid waste containing chromium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Chromium/ |
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| 소화 | Excerpt from ERG Guide 140 [Oxidizers]:SMALL FIRE: Use water. Do not use dry chemicals or foams. CO2 or Halon® may provide limited control.LARGE FIRE: Flood fire area with water from a distance. Do not move cargo or vehicle if cargo has been exposed to heat. If it can be done safely, move undamaged containers away from the area around the fire.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: For ammonium nitrate products: Do not fight cargo fire. Withdraw, evacuate and isolate area for at least 1600 meters (1 mile). Treat as an explosive (ERG Guide 112). Do not enter area for 24 hours or until expert advice has been provided. Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. (ERG, 2024)Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:SMALL FIRE: Dry chemical, CO2 or water spray.LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesIn case of fire in the surroundings, use appropriate extinguishing media. |
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| 응급 조치 | Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . |
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| 응급 처치 | INHALATION: remove victim to fresh airget medical attention.INGESTION: get immediate medical helpif vomiting is not spontaneous, give an emetic such as soapy water followed by copious water intake.EYES: immediately flush with plenty of water for at least 15 min.consult physician promptly.SKIN: immediately flush with plenty of water for at least 15 min.persistent dermatitis should be referred to a physicianwash contaminated skin or clothing until chromate color disappears. (USCG, 1999)Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:Refer to the "General First Aid" section. (ERG, 2024) |
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| 안전 보관 | Provision to contain effluent from fire extinguishing. Separated from combustible substances, reducing agents and food and feedstuffs. Dry. Well closed. Store in an area without drain or sewer access. |
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| 소화 절차 | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Extinguish fire using agent suitable for type of surrounding fire (material itself does not burn or burns with difficulty.)If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.) /Sodium chromate (Environmentally hazardous substances, liquid, N.O.S.)Sodium chromate (Environmentally hazardous substances, solid, N.O.S.)Sodium chromate (Toxic solids, organic, N.O.S.)Sodium chromate (Toxic liquid, inorganic, N.O.S.)Sodium chromate (toxic solid, inorganic, N.O.S.)/For more Fire Fighting Procedures (Complete) data for SODIUM CHROMATE (7 total), please visit the HSDB record page. |
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| 보관 조건 | Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.Store away from combustiblesavoid high temp /Sodium cmpd/Store in a secure poison location. ... Store in tightly closed containers in a cool, well-ventilated area away from combustibles, organics, or other easily oxidized materials. Where possible, automatically transfer materials from drums or other storage containers to process containers. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045. |
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| 정리 방법 | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dustEnvironmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoidedMethods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.Land Spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. /Sodium chromate soln/Environmental considerations: Land Spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /Sodium chromate (Environmentally hazardous substances, solid, N.O.S.)Sodium chromate (Toxic liquid, inorganic, N.O.S.)Sodium chromate (Toxic solid, inorganic, N.O.S.)/Environmental considerations: Land Spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. /Sodium chromate (Environmentally hazardous substances, liquid, N.O.S.)/For more Cleanup Methods (Complete) data for SODIUM CHROMATE (10 total), please visit the HSDB record page. |
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| 비화재 누출 대응 | Excerpt from ERG Guide 140 [Oxidizers]:Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Do not get water inside containers.SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover looselymove containers from spill area.SMALL LIQUID SPILL: Use a non-combustible material like vermiculite or sand to soak up the product and place into a container for later disposal.LARGE SPILL: Dike far ahead of liquid spill for later disposal. (ERG, 2024)Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024) |
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| 처리 방법 | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D007, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Chromium/Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubberContaminated packaging: Dispose of as unused product.Dissolved or soluble chromium cmpd in which the chromium is more than trivalent, thus chromate waste above all, must be reduced chemically and precipitated as chromium (III) hydroxide. The precipitated sludges must be compacted by partial dewatering to enable disposal and prevent degradation of waters and ground water. Normal standards for the introduction of electroplating waste water into the sewerage system tolerate a maximum of 2 mg of chromium per l of waste water, dissolved or undissolved. Where no central detoxification, neutralization, and sludge dewatering systems are available, these waste water treatment measures must be taken in the plants. To this end, chromate-containing wastes, baths, eluates, and semiconcentrates must be collected separately. Reduction to trivalent chromium is usually accomplished with the aid of sodium bisulfate in sulfuric acid soln (pH 2-3). Under certain circumstances, agents such as sulfur dioxide from waste gases or sulfite-containing liquids obtained from the scrubbing of waste gas, iron filings, brass or aluminum chips can be profitably used for reduction. The subsequent precipitation of the chromium is accomplished by alkalizing to pH 8-9waste alkali soln or alkaline treated waste water, for example from cyanide detoxification, can be used here. The sludge is usually dewatered through a process of sedimentation in settling basins, decanting and pressing the thin sludge in chamber filter presses, insofar as it cannot be recycled. Depending on local conditions, the compacted sludge (residual water content 60-70%) is disposed of in SRP:/hazardous waste landfill/. Recommendable methods: Reduction, solidification, & landfill. Not recommendable methods: Discharge to sewer & thermal destruction. Peer-review: The filtrate should be diluted and discharged to sewer. Chromium containing sludges cannot be disposed of in incinerators, as the trivalent chromium is reoxidized to hexavalent chromium in the heat. (Peer-review conclusions oSRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.For more Disposal Methods (Complete) data for SODIUM CHROMATE (11 total), please visit the HSDB record page. |
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| 누출 처리 | Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. |
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| Preventive Measures | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dustEnvironmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.For more Preventive Measures (Complete) data for SODIUM CHROMATE (12 total), please visit the HSDB record page. |
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| Isolation and Evacuation | Excerpt from ERG Guide 140 [Oxidizers]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet).FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. If ammonium nitrate products are in a tank, rail car or truck and involved in a fire, ISOLATE for 1600 meters (1 mile) in all directionsalso, initiate evacuation including emergency responders for 1600 meters (1 mile) in all directions. (ERG, 2024)Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024) |
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| Treatment | There is no know antidote for chromium poisoning. Exposure is usually handled with symptomatic treatment. (L16) |
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| 상호 작용 | Sodium chromate consistently stimulated organic binding of iodine & thiocyanate oxidation, & potentiated effects of submaximal concn of thyroid-stimulating hormone on these processes, in bovine thyroid slices.The effect of vitamin B2, which is capable of reducing chromium(VI) to chromium(V), on chromosomal aberrations and mutation caused by Na2CrO4 was investigated in Chinese hamster V79 cells. Pretreatment with 200 uM vitamin B2 (riboflavin) for 24 hr prior to exposure to Na2CrO4 (2.5-5 uM) resulted in an increase of metal-induced chromosomal aberrations and mutation at the HGPRT locus. These and other previous studies suggest that vitamin B2 enhances the clastogenic and mutagenic action of chromate compounds, through its ability to directly reduce chromium(VI) in cells.The effect of vitamin E on chromosomal aberrations and mutation caused by Na2CrO4 was investigated in Chinese hamster V79 cells. Pretreatment with 25 uM alpha-tocopherol succinate (vitamin E) for 24 hr prior to chromate exposure (2.5-5 uM) resulted in a decrease of metal-induced chromosomal aberrations. Na2CrO4 (2.5-7.5 uM) induced mutations at the HGPRT locus, but only within a very limited concentration range. This mutagenic response could also be suppressed by pretreatment with vitamin E. These results suggest that vitamin E can protect cells from the clastogenic and mutagenic action of chromate compounds, possibly through its ability to scavenge chromium(V) and/or free radicals.The effect of pretreatment with ascorbic acid (vitamin C) on chromate-induced DNA damage, cytotoxicity, and enzyme inhibition as well as on the cellular reduction of chromium(VI) was investigated using Chinese hamster V-79 cells. Cellular pretreatment with nontoxic levels of 1 mM ascorbic acid for 24 hr prior to exposure resulted in a significant increase (1.7-fold) in cellular levels of this vitamin. Alkaline elution assays demonstrated that this pretreatment decreased cellular levels of Na2CrO4-induced alkali-labile sites while the numbers of DNA-protein crosslinks produced by chromate increased. In colony-forming assays, pretreatment with ascorbic acid enhanced the cytotoxicity of chromate. However, the inhibition of glutathione reductase attributed to Na2CrO4 was attenuated by this pretreatment. Under the same experimental condition, the uptake of chromate in pretreated cells was found to increase. ESR studies revealed that cellular pretreatment with ascorbic acid reduced the level of chromium(V) intermediate and increased the level of chromium(III) complex, indicating that cellular reduction of chromium(VI) to chromium(III) was accelerated by this vitamin. These results suggest that ascorbic acid decreases chromate-induced alkali-labile sites and chromium inhibition of glutathione reductase, but it enhances DNA-protein cross-links and cytotoxicity caused by this metal through its ability to directly reduce chromium(VI).For more Interactions (Complete) data for SODIUM CHROMATE (8 total), please visit the HSDB record page. |
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| 건강 영향 | Hexavalent chromium is a known carcinogen. Chronic inhalation especially has been linked to lung cancer. Hexavalent chromium has also been know to cause reproductive and developmental defects. (A12) |
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| 생태독성 수치 | Selected ranked Species Mean Acute Values for saltwater species are as follows: Nassarius obsoletus (mud snail) 105,000 ug/L, Fundulus heteroclitus (mummichog) 74,010 ug/L, Menidia menidia (Atlantic silverside) 15,280 ug/L, Crassostrea gigas (Pacific oyster) 4,538 ug/L, Mytilus edulis (blue mussel) 4,469 ug/L, Mysidopsis bahia (mysid shrimp) 2,030 ug/L, and Nereis virens (polychaete worm) 2,000 ug/L. The saltwater Final Acute Value of 2,158 ug/L for chromium(6+) was calculated from the Genus Mean Acute Values. /Hexavalent chromium/EC50Species: Lemna minor (Duckweed)Conditions: freshwater, static, 25 °CConcentration: 584 ug/L for 7 days (95% confidence interval: 328-1060 ug/L)Effect: growth, decreased weightConcentration: 155 ug/L for 7 days (95% confidence interval: 28-2770 ug/L)Effect: biochemistry, decreased chlorophyllConcentration: 80 ug/L for 7 days (95% confidence interval: 13-6620 ug/L)Effect: biochemistry, decreased carotenoid contentConcentration: 2300 ug/L for 7 days (95% confidence interval: 870-8500 ug/L)Effect: growth, decreased growth rate |
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| 유해 작용 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.Dermatotoxin - Skin burns.Skin Sensitizer - An agent that can induce an allergic reaction in the skin.Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens.ACGIH Carcinogen - Confirmed Human. |
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| 노출 경로 | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.Inhalation (L16)oral (L16)dermal (L16) |
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| 독성 요약 | IDENTIFICATION AND USE: Sodium chromate forms yellow orthorhombic crystals. It is used in inks, dyeing, paint pigment, leather tanning, other chromates, and protection of iron against corrosion. (51)Chromium, as sodium chromate ((51)Cr), is used to label red blood cells so that red cell survival and red cell volume can be measured. HUMAN EXPOSURE AND TOXICITY: Eye contact can cause severe damage with possible loss of vision. A 51-year-old man committed suicide by ingesting a fatal dose of sodium chromate solution. He unexpectedly lost consciousness 6 hrs after the ingestion and died approximately 20.5 hrs later. The patient's death was assumed to have been caused by circulatory collapse due to internal bleeding and the direct toxicity of chromate compounds with hepatic malfunction and possibly disseminated intravascular coagulation. None of the results showed statistically significant differences that would suggest an excess risk for malignant neoplasms, particularly lung cancer, among workers engaged in the manufacture of chromate pigment in Japan. When tested in cultured human bronchial epithelial cells, it was found that 1, 2.5, 5 and 10 uM sodium chromate induced 66, 35, 0 and 0% relative survival, respectively. The amount of chromosome damage increased with concentration after 24 hr exposure to sodium chromate. Specifically, 1, 2.5 and 5 microM damaged 25, 34 and 41% of metaphase cells with the total amount of damage reaching 33, 59 and 70 aberrations per 100 metaphases, respectively. Ten micromolar sodium chromate induced profound cell cycle delay and no metaphases were found. In other experiment, cells exposed to 1 microM sodium chromate for 24, 48 and 72 hr induced 23, 13 and 17% damaged metaphases, respectively. ANIMAL STUDIES: Rats treated ip with sodium chromate(VI) at 2 mg/kg chromium 3 times per week for up to 60 days developed liver damage. In a study examining the effects of chromium(VI) on motor activity, no effects were noted in six rats provided wiHexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produced during reoxidation of pentavalent chromium by hydrogen peroxide molecules present in the cell. Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, chromium-DNA adducts, chromosomal aberrations and alterations in cellular signaling pathways. It has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. It can also cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (A12, L16, A34, A35, A36) |
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| 생태독성 발췌 | /AQUATIC SPECIES/ ... the cytotoxic and clastogenic effects of Cr(VI) in human (Homo sapiens) and sperm whale (Physeter macrocephalus) skin fibroblasts /were compared/. ...Data show that increasing concentrations of both particulate /lead chromate/ and soluble /sodium chromate/ Cr(VI) induce increasing amounts of cytotoxicity and clastogenicity in human and sperm whale skin cells. Furthermore, the data show that sperm whale cells are resistant to these effects exhibiting less cytotoxicity and genotoxicity than the human cells. Differences in Cr uptake accounted for some but not all of the differences in particulate and soluble Cr(VI) genotoxicity, although it did explain the differences in particulate Cr(VI) cytotoxicity. Altogether, the data indicate that Cr(VI) is a genotoxic threat to whales, but also suggest that whales have evolved cellular mechanisms to protect them against the genotoxicity of environmental agents such as Cr(VI)./AQUATIC SPECIES/ Toxic effects were studied in rainbow trout exposed to sodium chromate solution. When survival was used as the criterion, chromium was more toxic at pH 6.5 than at pH 7.8 at all life stages studied. For trout in the embryo through juvenile exposure study, the lowest concentrations increasing mortality were 0.2 mg/L at pH 6.5 and 2.0 mg/L at pH 7.8./AQUATIC SPECIES/ The survival of Rhithropanopeus harrisii larvae from hatching to first crab stage occurred in sodium chromate concentrations from 1.1 to 29.1 ppm. The estimated median lethal concentration (LC50) for complete zoeal development was 17.8 ppm sodium chromate and 13.7 ppm for development to first crab stage. A concentration of 1.1 ppm sodium chromate was nontoxic, whereas concentrations of 7.2 and 14.5 ppm were sublethal, with 29.1-58.1 ppm being acutely toxic./AQUATIC SPECIES/ Sea turtles are a charismatic and ancient ocean species and can serve as key indicators for ocean ecosystems, including coral reefs and sea grass beds as well as coastal beaches. Genotoxicity studies in the species are absent, limiting our understanding of the impact of environmental toxicants on sea turtles. Hexavalent chromium (Cr(VI)) is a ubiquitous environmental problem worldwide, and recent studies show it is a global marine pollutant of concern. Thus, we evaluated the cytotoxicity and genotoxicity of soluble and particulate Cr(VI) in hawksbill sea turtle cells. Particulate Cr(VI) was both cytotoxic and genotoxic to sea turtle cells. Concentrations of 0.1, 0.5, 1, and 5 ug/sq cm lead chromate induced 108, 79, 54, and 7% relative survival, respectively. Additionally, concentrations of 0, 0.1, 0.5, 1, and 5ug/sq cm lead chromate induced damage in 4, 10, 15, 26, and 36% of cells and caused 4, 11, 17, 30, and 56 chromosome aberrations in 100 metaphases, respectively. For soluble Cr, concentrations of 0.25, 0.5, 1, 2.5, and 5 uM sodium chromate induced 84, 69, 46, 25, and 3% relative survival, respectively. Sodium chromate induced 3, 9, 9, 14, 21, and 29% of metaphases with damage, and caused 3, 10, 10, 16, 26, and 39 damaged chromosomes in 100 metaphases at concentrations of 0, 0.25, 0.5, 1, 2.5, and 5uM sodium chromate, respectively. These data suggest that Cr(VI) may be a concern for hawksbill sea turtles and sea turtles in general.For more Ecotoxicity Excerpts (Complete) data for SODIUM CHROMATE (7 total), please visit the HSDB record page. |
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| Signs and Symptoms | Burning sensation. Sore throat. Cough. Wheezing. Laboured breathing.Redness. Pain. Skin burns.Redness. Pain. Blurred vision. Severe deep burns.Nausea. Vomiting. Abdominal pain. Burning sensation. Diarrhoea. Shock or collapse.Breathing hexavalent chromium can cause irritation to the lining of the nose, nose ulcers, runny nose, and breathing problems, such as asthma, cough, shortness of breath, or wheezing. Ingestion of hexavalent chromium causes irritation and ulcers in the stomach and small intestine, as well as anemia. Skin contact can cause skin ulcers. (L16) |
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| ICSC Environmental Data | The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment. |
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| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ A corrosive. Eye contact can cause severe damage with possible loss of vision./CASE REPORTS/ An interesting case of acute poisoning by chromate compounds is reported. A 51-year-old man committed suicide by ingesting a fatal dose of sodium chromate solution. He unexpectedly lost consciousness 6 hr after the ingestion and died approximately 20.5 hr later. An examination of the blood showed noticeable hepatic damage and thrombocytopenia. The postmortem examination revealed extensive bleeding in the alimentary tract and a severe hepatic lesion due to hepatocellular necrosis. However, the renal disorder was unusually light in the microscopic and clinical findings. Moreover, the renal lesion was observed mainly in the distal tubules instead of the proximal tubules which is more typical in cases of acute poisonings by diverse heavy metals including chromium. The patient's death was assumed to have been caused by circulatory collapse due to internal bleeding and the direct toxicity of chromate compounds with hepatic malfunction and possibly disseminated intravascular coagulation (DIC)./CASE REPORTS/ A 29-year-old male welder reported systemic reactions after exposure to chromium. Inhalation challenge testing to 29 ug/cu m of sodium chromate aerosol resulted in late appearing systemic urticaria, angioedema, and severe bronchospasm that occurred at the same time as a threefold rise in plasma histamine. A direct leukocyte inhibitory factor test to 5.5 X 10(-6)mol/L Na2CrO4 was positive. Although the mechanism of this reaction is unknown, the positive leukocyte inhibitory factor and the general acceptance of hexavalent chromium as a contact skin sensitizer suggest that cell-mediated mechanisms could be involved./SURVEILLANCE/ In 1975, five manufacturers of chromate pigment in Japan were examined in a study of the carcinogenicity of chromates. These companies were producing lead chromate, zinc chromate, molybdate orange and/or strontium chromate. The current study covers a cohort of 666 workers involved in the manufacture of chromate pigment for at least 1 year between 1950 and 1975. The workers were followed up for 15-40 years, until 1989. Many previous reports have found an excess lung cancer risk among workers involved in the manufacture of chromate pigments and chromate chemicals. In the current study, subjects were classified on the basis of years worked, years of observation, characteristics of company, type of work engaged in for the longest period of time, and involvement in the manufacture of zinc chromate. Mortality was compared with that of all Japanese males by means of the person-year method. The route of exposure was primarily inhalation through the respiratory system. None of the results showed statistically significant differences that would suggest an excess risk for malignant neoplasms, particularly lung cancer, among workers engaged in the manufacture of chromate pigment in Japan.For more Human Toxicity Excerpts (Complete) data for SODIUM CHROMATE (13 total), please visit the HSDB record page. |
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| Artificial Pollution Sources | Sodium chromate's use in drilling muds(1) will result in its direct release to the environment(SRC). About one metric ton of sodium chromate has been used annually in drilling muds for an average West Texas well to combat fatigue corrosion cracking of drill strings(1). |
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| FIFRA 요건 | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Sodium chromate is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0132Pesticide type: Fungicide (Wood preservative)Registration Standard Date: 06/01/88, 09/10/86Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): Sodium chromateAI Status: The active ingredient is no longer contained in any registered products. Thus, we characterize it as "cancelled." |
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| 대기 기준 | ... Substances for which a Federal Register notice has been published that included consideration of the serious health effects, including cancer, from ambient air exposure to the substance. Chromium is included on this list. /Chromium/Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Chromium compounds is included on this list. /Chromium compounds/ |
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| CERCLA 보고 수량 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b). |
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| 청정수법 요건 | Sodium chromate is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Chromium and compounds/ |
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| State Drinking Water Standards | (CA) CALIFORNIA 10 ug/L /Hexavalent Chromium/ |
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| 주 식수 지침 | (ME) MAINE 35 ug/L /Cr VI) |
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| Federal Drinking Water Standards | Maximum contaminant level for inorganic contaminants: Contaminant: ChromiumMCL 0.1 mg/L. /Chromium/ |
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| 연방 식수 지침 | Maximum contaminant level goal for inorganic contaminants: Contaminant: ChromiumMCLG 0.1 mg/L. /Chromium/ |
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