기본 정보
- 표준 SMILES
CC(C)N1CCC(N(C(=O)Cc2ccccc2)c2ccc(Cl)cc2)CC1- InChIKey
XHOJAWVAWFHGHL-UHFFFAOYSA-N- 분자식
- C22H27ClN2O
- 평균 분자량
- 370.9 g/mol
- 단동위원소 질량
- 370.18119116
개요
Lorcainide is a member of acetamides.
이름 및 식별자
- 우선 이름
- Lorcainide
- IUPAC
- N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide
- 영어명
- Lorcainide
- 분자식
- C22H27ClN2O
- 분자량
- 370.92
이름 및 동의어
LORCAINIDE59729-31-6lorcainidLorcainidaLorcainidumKGJ2T0N7IQRo 13-10424'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilideN-(4-Chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl)benzeneacetamideDTXSID2023226RO-13-1042Benzeneacetamide, N-(4-chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl)-
이름 더 보기
R-15889LorcamideLopantrolRo-13。1042Lorivox：RemivoxLorcainide USP/EP/BPN-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamideN-(4-Chlorophenyl)-N-[1-(1-methylethyl)piperidin-4-yl]benzeneacetamideN-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
N-(4-chlorophenyl)-2-phenyl-N-[1-(propan-2-yl)piperidin-4-yl]acetamideBenzeneacetamide, N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]-N-(4-chlorophenyl)-2-phenyl-N-(1-(propan-2-yl)piperidin-4-yl)acetamideRefChem:154097R15889DTXCID703226C01BC07N-(4-chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl)benzeneacetamide.HCl
데이터베이스 식별자
- CAS
59729-31-6- PubChem CID
- 42884
- DTXSID
DTXSID2023226- ChEMBL
CHEMBL87543- ChEBI
CHEBI:135568- UNII
- KGJ2T0N7IQ
- Nikkaji
- J18.310E
물성
구조 계산 물성
- XLogP
- 4.6
- 극성 표면적
- 23.6 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 26
- 형식 전하
- 0
- 복잡도
- 433
실험 및 물리화학적 성질
LogP
4.85
4.85
Melting Point263 °C
Physical DescriptionSolid
물리화학적 성질
- 녹는점
- 263 °C · 263 °C
- 끓는 점
- 503 · 503.0±50.0 °C(Predicted)
- 밀도
- 1.161 · 1.161±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 9.48 · 9.48±0.20(Predicted)
안전 및 규제
안전 데이터
- 독성
- LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom)
화학 및 산업
약리 정보
ATC Code
C - Cardiovascular system
QC - Cardiovascular system
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Cellular LocationsMembrane
응용 분야
용도Cardiac depressant (anti-arrhythmic).
상·하류 제품 정보
상류 원료
공급사5 곳
Sinoway Industrial co., ltd.+86-0592-5800732 +86-13806035118 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]
武汉德拜技术有限公司18086626237 18086626237 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
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