기본 정보
- 표준 SMILES
C=CCN1CCCC1CNC(=O)c1cc2n[nH]nc2cc1OC- InChIKey
KSEYRUGYKHXGFW-UHFFFAOYSA-N- 분자식
- C16H21N5O2
- 평균 분자량
- 315.37 g/mol
- 단동위원소 질량
- 315.16952491
개요
Alizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, including that which may occur postoperatively.
이름 및 식별자
- 우선 이름
- 6-Methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide
- IUPAC
- 6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide
이름 및 동의어
6-Methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamideNausilexUNII-P55703ZRZYSCHEMBL48936orb1689218SCHEMBL1649436SCHEMBL30089955GTPL11141KSEYRUGYKHXGFW-UHFFFAOYSA-NHY-A0125EINECS 261-710-6BRN 6432438
이름 더 보기
AC-22579DB-053369CS-0017442NS00009083T60813Q6318291H-Benzotriazole-5-carboxamide, 6-methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-6-Methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1H-benzotriazole-5-carboxamide
데이터베이스 식별자
- CAS
59338-93-1- PubChem CID
- 43008
- DTXSID
DTXSID10866755- Nikkaji
- J10.911H
물성
구조 계산 물성
- XLogP
- 1.5
- 극성 표면적
- 83.1 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 23
- 형식 전하
- 0
- 복잡도
- 433
실험 및 물리화학적 성질
DrugsPharmaceuticals
LogP
1.79
2.22
Solubility4.95e-01 g/L
Melting Point139 °C
Physical DescriptionSolid
화학 및 산업
약리 정보
PharmacodynamicsAlizapride is a dopamine antagonist.
Mechanism of Action
The anti-emetic action of Alizapride is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)—this action prevents nausea and vomiting triggered by most stimuli. Structurally similar to metoclopramide and, therefore, shares similar other atributres related to emesis and prokinetics.
Biological Half-Life3 hours
Absorption, Distribution and Excretionrenal
Cellular LocationsMembrane
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
연결된 노트
불러오는 중…