Astromicin

HCID 5284517CAS 55779-06-1

기본 정보

표준 SMILES: CO[C@H]1[C@@H](O)[C@H](N)[C@@H](O[C@H]2O[C@H]([C@H](C)N)CC[C@H]2N)[C@H](O)[C@@H]1N(C)C(=O)CN
InChIKey: BIDUPMYXGFNAEJ-APGVDKLISA-N
분자식: C17H35N5O6
평균 분자량: 405.5 g/mol
단동위원소 질량: 405.25873384

개요

Astromicin is an amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms. It has a role as a metabolite and an antibacterial agent. It is an amino cyclitol glycoside, an aminoglycoside antibiotic, a diol, a monocarboxylic acid amide and a primary amino compound.

이름 및 식별자

우선 이름: Astromicin
IUPAC: 2-amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide
영어명: FORTIMICIN
분자식: C17H35N5O6
분자량: 405.49

이름 및 동의어

AstromicinFortimicin A55779-06-1AstromicinaAstromicineAntibiotic KW-1070AstromicinumASTMXK-70-1DTXSID2022624KW 1070XK 70-1

이름 더 보기

AstricinFORTIMYCINFORTIMICINASTROMYCINfortimicinaFortimycin Aantibiotickw-1070

7JHD84H15JKW-10704-Amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositolDTXCID602624CHEBI:379232-amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide4-amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositolN-[(1S,2R,3R,4S,5S,6R)-4-amino-3-({(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]tetrahydro-2H-pyran-2-yl}oxy)-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylglycinamide

데이터베이스 식별자

CAS: 55779-06-1
PubChem CID: 5284517
DTXSID: DTXSID2022624
ChEMBL: CHEMBL3084803
ChEBI: CHEBI:37923
UNII: 7JHD84H15J
Nikkaji: J34.182G

물성

구조 계산 물성

XLogP: -4.4
극성 표면적: 193 Å²
수소 결합 공여자 수: 6
수소 결합 수용자 수: 10
회전 가능 결합 수: 6
무거운 원자 수: 28
형식 전하: 0
복잡도: 528

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Antibiotics

물리화학적 성질

녹는점: 200 ° · >200° (dec)
끓는 점: 526.82 °C · 526.82°C (rough estimate)
밀도: 1.0897 · 1.0897 (rough estimate)
굴절률: 1.76 · 1.7600 (estimate)
산도 계수 (pKa): 13.16 · 13.16±0.70(Predicted)

안전 및 규제

안전 데이터

독성: LD50 (of the sulfate salt) in mice (mg/kg): 380 i.v.; 400 s.c. (Nara, 1977)

화학 및 산업

상·하류 제품 정보

상류 원료

공급사9 곳

北京华美互利生物化工010-56205725 · [email protected]

Shaanxi Cuikang Pharmaceutical Technology Co., Ltd+86-13119157289 · [email protected]

杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]

BOC Sciences16314854226; +8616314854226 · [email protected]

浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]

추가 설명 · 1건

정의ChEBI: An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at posi ion 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is adm nistered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms.

연결된 노트

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