Arachidonyl-2-chloroethylamide

HCID 5311006CAS 220556-69-4
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCCl
InChIKey
SCJNCDSAIRBRIA-DOFZRALJSA-N
분자식
C22H36ClNO
평균 분자량
366 g/mol
단동위원소 질량
365.24854245

개요

Arachidonyl-2'-chloroethylamide is a fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). It has a role as a CB2 receptor agonist, a CB1 receptor agonist and a neuroprotective agent. It is a secondary carboxamide, a fatty amide, an organochlorine compound and a synthetic cannabinoid. It is functionally related to an arachidonic acid.

이름 및 식별자

우선 이름
Arachidonyl-2-chloroethylamide
IUPAC
(5Z,8Z,11Z,14Z)-N-(2-chloroethyl)icosa-5,8,11,14-tetraenamide
영어명
ACEA
분자식
C22H36ClNO
분자량
365.98

이름 및 동의어

arachidonyl-2-chloroethylamideArachidonyl-2'-chloroethylamide(5Z,8Z,11Z,14Z)-N-(2-chloroethyl)icosa-5,8,11,14-tetraenamideACEA cpdCHEBI:191854N-(2-chloroethyl)-5,8,11,14-eicosatetraenamideRefChem:113680acea220556-69-4CHEMBL151167MFCD02683581ACEA; 2'-chloro-AEA
이름 더 보기
2'-CHLORO-AEAACEA (ethanol solution)Terfenadine Impurity 23Arachidonoyl 2'-ChloroethylamideACEA, 5mg/ml solution in ethanolEicosapentaenoic Acid Impurity 51ARACHIDONYL-2'-CHLOROETHYLAMIDE HYDRATE
N-(2-chloroethyl)icosa-5,8,11,14-tetraenamideC22H36ClNOArachidonoyl-2-chloroethylamideN-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamideGTPL738orb1692278SCHEMBL1517676DTXSID60274346

데이터베이스 식별자

CAS
220556-69-4
PubChem CID
5311006
DTXSID
DTXSID60274346
ChEMBL
CHEMBL151167
ChEBI
CHEBI:191854
Nikkaji
J1.087.037B

물성

구조 계산 물성

XLogP
6.6
극성 표면적
29.1 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
1
회전 가능 결합 수
16
무거운 원자 수
25

물리화학적 성질

저장 조건
20 °C · −20°C
용해도
DMSO: 용해될 수 있다
물리적 상태
기름
색상
옅은 노랑
InChIKey
SCJNCDSAIRBRIA-DOFZRALJSA-N
SMILES
C(NCCCl)(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC

안전 및 규제

안전 데이터

wgk
3

화학 및 산업

응용 분야 · 2건

개요Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.

용도A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).

공급사31 곳

陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
江苏南创化学与生命健康研究院有限公司15720605021
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
星基医药（上海）有限公司15705593425
United Life Science020-82099279 18988941402 · [email protected]

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