Invertin
Doxycycline USP · DOXYCYCLINE HYDRATE · Power v1 · NSC-56228 · Strong v1 · Doxycyeline HCL · oxycyclinemonohydrate · DOXYCYCLINE MONOHYDRATE
식별자 및 물리적 특성
| CAS No. | 17086-28-1 |
|---|---|
| 분자식 | C22H26N2O9 |
| 평균 분자량 | 462.4 g/mol |
| SMILES | C[C@H]1c2cccc(O)c2C(O)=C2C(=O)[C@]3(O)C(O)=C(C(N)=O)C(=O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.O |
| InChIKey | XQTWDDCIUJNLTR-PGTYNCOMNA-N |
| PubChem CID | 54684461 |
| ChEMBL | CHEMBL1200699 |
| ChEBI | CHEBI:60648 |
| EC No. | 605-591-4 |
| DTXSID | DTXSID401045241 |
화학 및 물리적 성질
| 극성 표면적 | 183 |
|---|---|
| 수소 결합 공여자 수 | 7 |
| 수소 결합 수용자 수 | 10 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 33 |
| 형식 전하 | 0 |
| 복잡도 | 956 |
| 의약품 | Pharmaceuticals -> Antibiotics |
| 녹는점 | 167-168℃ |
| 저장 조건 | Sealed in dry,Store in freezer, under -20°C |
| 용해도 | DMSO: 용해성1mg/mL |
| 물리적 상태 | 분말 또는 결정 |
| 색상 | 연노랑 |
| 용해도 | 에탄올이나 메탄올에 용해됩니다. 물에 거의 용해되지 않습니다. 묽은 산, 알칼리 수산화물 및 디메틸 설폭사이드에 용해됩니다. |
| 주요 응용 | 의약품(소분자) |
| InChIKey | XQTWDDCIUJNLTR-PGTYNCOMNA-N |
| SMILES | [C@@]12([H])[C@@H](O)[C@@]3([H])C(C(=O)C4C(O)=CC=CC=4[C@@H]3C)=C(O)[C@]1(O)C(=O)C(C(=O)N)=C(O)[C@H]2N(C)C.O |&1:0,2,4,16,20,30,r| |
화학적 성질
Doxycycline monohydrate is a Yellow, crystalline powder. It is soluble in ethanol or methanol. It has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. It is very slightly soluble in water.
안전 및 규제
| GHS 분류 | DangerH302 (43.2%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 148 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Hazard Traits - Developmental ToxicityDoxycycline monohydrate: Does not have an individual approval but may be used under an appropriate group standardInvertin: Does not have an individual approval but may be used under an appropriate group standard |
| Hazard Classes and Categories | Acute Tox. 4 (43.2%) |
| 수질 위해 등급(WGK) | 3 |
| 관세 코드 | 29413000 |
| 위험 문구(R) | 36/37/38-22-63 |
| 위험 표시 | Xi,Xn |
| 안전 문구(S) | 26-36/37 |
| 위험 등급 | Acute Tox. 4 Oral |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.
용도
Doxycycline Monohydrate is used to treat bacterial infections, Lyme disease, chlamydia, Rocky Mountain Spotted Fever, and other susceptible bacterial infections. It is an antibiotic with bacteriostatic properties.Tetracycline antibacterial.
일반 설명
Doxycycline was synthesized by Pfizer starting with either tetracycline or oxytetracycline in 1958. It shows about fourfold higher antibacterial activity than tetracycline against a variety of pathogens. Doxycycline shows higher oral absorption than tetracycline, and its concentration in tissue is higher and maintained longer. Hyclate is a preparation of doxycycline containing one mole of hydrochloric acid and one-half mole each of ethanol and water per mole of doxycycline.