레지니페라톡신

레지니페라톡신 · RTX · RESINIFERATOXIN · [3H]resiniferatoxin · Resiniferatoxin >99% · Resiniferatoxin (80%) · Resiniferatoxin, 98.5% · RESINIFERATOXIN,HIGHPURITY

https://huagongshe.com/ko/chemical/5702546

식별자 및 물리적 특성

CAS No.	57444-62-9
분자식	C37H40O9
평균 분자량	628.7 g/mol
단동위원소 질량	628.26723286 g/mol
SMILES	C=C(C)[C@]12C[C@@H](C)[C@@]34O[C@](Cc5ccccc5)(O[C@@H]1[C@@H]3C=C(COC(=O)Cc1ccc(O)c(OC)c1)C[C@]1(O)C(=O)C(C)=C[C@@H]41)O2
InChIKey	DSDNAKHZNJAGHN-MXTYGGKSSA-N
PubChem CID	5702546
ChEMBL	CHEMBL17976
ChEBI	CHEBI:8809
EC No.	637-354-6
DTXSID	DTXSID00894764
현지명	레지니페라톡신

화학 및 물리적 성질

XLogP	4.5
극성 표면적	121
수소 결합 공여자 수	2
수소 결합 수용자 수	9
회전 가능 결합 수	9
무거운 원자 수	46
형식 전하	0
복잡도	1,330
끓는 점	768.7±60.0 °C(Predicted)
밀도	1.35±0.1 g/cm3(Predicted)
저장 조건	-20°C
용해도	DMSO에서 100mM, 에탄올에서 50mM까지 용해 가능
물리적 상태	고체
pKa(산도 계수)	9.85±0.20(Predicted)
색상	흰색에서 황백색까지
생물학적 소스	Euphorbia poisonii
BRN	5371150
안정성	제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
InChIKey	DSDNAKHZNJAGHN-MXTYGGKSSA-N
SMILES	C1(CC(OCC2C[C@@]3(O)[C@]([H])([C@]45O[C@]6(CC7=CC=CC=C7)O[C@]([H])([C@]4([H])C=2)[C@](C(C)=C)(C[C@H]5C)O6)C=C(C)C3=O)=O)=CC=C(O)C(OC)=C1

화학적 성질

white to off-white solid

안전 및 규제

GHS 분류	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P260, P264, P270, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 44 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard Classes and Categories	Acute Tox. 3 (100%)
건강 영향	Resiniferatoxin is a neurotoxin that targets afferent sensory neurons involved in nociception. It evokes a powerful irritant effect followed by desensitization and analgesia. (L1244)
노출 경로	Oral (ingestion) (L1817)dermal (L1817)
독성 요약	Resiniferatoxin activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain). RTX causes a novel ion channel in the plasma membrane of sensory neurons, the transient receptor potential vanilloid 1, to become permeable to cations, most particularly the calcium cation. This evokes a powerful irritant effect followed by desensitization and analgesia. (L1244)
Signs and Symptoms	Resiniferatoxin evokes a powerful irritant effect followed by desensitization and analgesia. (L1244)
Carcinogen Classification	No indication of carcinogenicity to humans (not listed by IARC).
수질 위해 등급(WGK)	3
RTECS 번호	CY1633700
운송 번호(UN)	UN 2928 6.1/PG 2
관세 코드	29329990
위험 문구(R)	25-35
위험 표시	T
안전 문구(S)	26-36/37/39-45
포장분류	II
위험 등급	6.1(a)Acute Tox. 3 OralSkin Corr. 1A
F 고인화성물질	10-23
저장 분류	6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

용도

Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2): for complex preparation for cryo-electron microscopy structural studies to test its effect towards immune responses toP.aeruginosa in sensory neurons associated with the cornea to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice