Ceftazidime Pentahydrate

HCID 6536864CAS 78439-06-2

기본 정보

표준 SMILES: CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O.O.O.O.O.O
InChIKey: NMVPEQXCMGEDNH-TZVUEUGBSA-N
분자식: C22H32N6O12S2
평균 분자량: 636.7 g/mol
단동위원소 질량: 636.15196246

개요

Ceftazidime pentahydrate is a hydrate that is the pentahydrate of ceftazidime, a cephalosporin having 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino and 3-pyridinium-1-ylmethyl side-groups. It contains a ceftazidime.

이름 및 식별자

우선 이름: Ceftazidime Pentahydrate
IUPAC: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrate

이름 및 동의어

Ceftazidime pentahydrate78439-06-2Ceftazidime hydrateDTXSID0045599CHEBI:3509DTXCID8025599RefChem:574982(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetylamino)-3-(pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate pentahydrateModacinGlazidimCeftazidime CRSTazicef (TN)

이름 더 보기

MFCD00153936(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrateCeftazidime Pentahydrate(Contain 1 equivalent of Na2CO3 as stabilizer)NCGC00017137-01Ceftazidime (USP)CAS-78439-06-2CEFTAZIDIME [USAN]CEFTAZIDIME [VANDF]

데이터베이스 식별자

CAS: 78439-06-2
PubChem CID: 6536864
DTXSID: DTXSID0045599
ChEMBL: CHEMBL3186392
ChEBI: CHEBI:3509
UNII: 9M416Z9QNR
EC Number: 616-626-8

물성

구조 계산 물성

극성 표면적: 250 Å²
수소 결합 공여자 수: 8
수소 결합 수용자 수: 17
회전 가능 결합 수: 8
무거운 원자 수: 42
형식 전하: 0
복잡도: 1,020

실험 및 물리화학적 성질

Chemical ClassesOther Uses -> Pharmaceuticals

Human Drugs · 2건

Breast Feeding; Lactation; Anti-Infective Agents; Antibacterial Agents; Cephalosporins

Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antibacterial Agents; Cephalosporins

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 63 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazards SummaryMay cause allergic skin reaction and asthma; [Pfizer] Occupational asthma confirmed in a pharmaceutical worker; [Malo]

Hazard Classes and CategoriesSkin Sens. 1 (100%)

독성 정보

Adverse EffectsAsthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

Effects During Pregnancy and Lactation · 2건

◉ Summary of Use during Lactation

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 1건

Agents that are structurally similar to other CEPHALOSPORINS but have a broader spectrum of activity against bacteria than the first and second generation cephalosporins. These agents cover more resistant STREPTOCOCCUS, STAPHYLOCOCCUS, gram-positive anaerobes, and more resistant strains of HAEMOPHILUS, NEISSERIA, PROTEUS, ESCHERICHIA COLI, and KLEBSIELLA (HNPEK).

용도 및 제조

UsesA cephalosporin antibiotic; [Pfizer]

연결된 노트

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