카루모난

Carumonam

HCID 6540466CAS 87638-04-8

기본 정보

표준 SMILES: NC(=O)OC[C@@H]1[C@H](NC(=O)/C(=N\OCC(=O)O)c2csc(N)n2)C(=O)N1S(=O)(=O)O
InChIKey: UIMOJFJSJSIGLV-JNHMLNOCSA-N
분자식: C12H14N6O10S2
평균 분자량: 466.4 g/mol
단동위원소 질량: 466.02128265

개요

Carumonam is an N-sulfonated monobactam antibiotic. It has a role as an antibacterial drug. It is a conjugate acid of a carumonam(1-).

이름 및 식별자

우선 이름: Carumonam
IUPAC: 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-(carbamoyloxymethyl)-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyacetic acid
현지명: 카루모난
영어명: CARUMONAM
분자식: C12H14N6O10S2
분자량: 466.4

이름 및 동의어

Carumonam87638-04-8CarumonamumAMA 1080 FREE ACIDAMA-1080 FREE ACIDDTXSID3048312CHEBI:55486Ro 17-2301486890PI06(((2-((2-(((Aminocarbonyl)oxy)methyl)-4-oxo-1-sulfo-3-azetidinyl)amino)-1-(2-amino-4-thiazolyl)-2-oxoethylidene)amino)oxy)acetic acid (2S-(2alpha,3alpha(Z)))-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2S,3S)-2-[(carbamoyloxy)methyl]-4-oxo-1-sulfoazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)acetic acidAcetic acid, (((2-((2-(((aminocarbonyl)oxy)methyl)-4-oxo-1-sulfo-3-azetidinyl)amino)-1-(2-amino-4-thiazolyl)-2-oxoethylidene)amino)oxy)-, (2S-(2alpha,3alpha(Z)))-

이름 더 보기

카루모난AMA 1080CarlliIIonalnCARUMONAM USP/EP/BPRo-17-2301：A-masulinAntibiotic Ro 17-2301(2S)-2α-(Carbamoyloxymethyl)-3α-[[(Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-4-oxoazetidine-1-sulfonic acid[[[(Z)-2-[[(2S)-2α-[[(Aminocarbonyl)oxy]methyl]-4-oxo-1-sulfoazetidin-3α-yl]amino]-1-(2-aminothiazol-4-yl)-2-oxoethylidene]amino]oxy]acetic acid[[[(Z)-2-[[(2S,3S)-2-[[(Aminocarbonyl)oxy]methyl]-4-oxo-1-sulfoazetidin-3-yl]amino]-1-(2-amino-4-thiazolyl)-2-oxoethylidene]amino]oxy]acetic acid

Ro-17-2301((((1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-(((2S,3S)-2-((carbamoyloxy)methyl)-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)acetic acid2-((1-(2-amino-1,3-thiazol-4-yl)-2-(((2S,3S)-2-(carbamoyloxymethyl)-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxyacetic acid2-[[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-(carbamoyloxymethyl)-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyacetic acidRefChem:123844DTXCID1028287J01DF02(3S,4S)-3-(2-(2-aminothiazol-4-yl)-(Z)-2-carboxymethoxyiminoacetamido)-4-carbamoyloxymethyl-2-azetidinone-1-sulfonic acid

데이터베이스 식별자

CAS: 87638-04-8
PubChem CID: 6540466
DTXSID: DTXSID3048312
ChEMBL: CHEMBL1614658
ChEBI: CHEBI:55486
UNII: 486890PI06
Nikkaji: J23.309I

물성

구조 계산 물성

XLogP: -1.4
극성 표면적: 291 Å²
수소 결합 공여자 수: 5
수소 결합 수용자 수: 14
회전 가능 결합 수: 10
무거운 원자 수: 30
형식 전하: 0
복잡도: 858

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Antibiotics

물리화학적 성질

밀도: 2.13 · 2.13±0.1 g/cm3(Predicted)
산도 계수 (pKa): -0.43 · -0.43±0.60(Predicted)

화학 및 산업

약리 정보

ATC Code · 2건

J - Antiinfectives for systemic use

QJ - Antiinfectives for systemic use

응용 분야 · 1건

개요Canunonam is an injectable antibiotic, the second monobactam ever developed (the first being Squibb’s aztreonam). It is highly active against Gram negative bacteria, particularly pseudomom, and is reportedly effective in the treatment of pneumonia, cystitis, peritonitis and secondary infections.

상·하류 제품 정보

상류 원료

공급사16 곳

北京华美互利生物化工010-56205725 · [email protected]

陕西缔都医药化工有限公司+86-29-87569262 +86-15003564040 · [email protected]

上海孚一生物科技有限公司+86 (21) 61124340

湖北源梦生物科技有限公司027-68897569 18120462897 · [email protected]

上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]

추가 설명

정의ChEBI: An N-sulfonated monobactam antibiotic.

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