Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylmagnesium bromide
PhMgBr · bromophenylmagnesium · Phenylmagnesium bromide, 2.8M solution in Diethyl ether · Phenylmagnesi · nesium bromide · Phenylbromomagnesium · bromophenyl-magnesiu · (Bromomagnesio)benzene
식별자 및 물리적 특성
| CAS No. | 100-58-3 |
|---|---|
| 분자식 | C6.H5.Mg.Br |
| 평균 분자량 | 181.31 g/mol |
| SMILES | [Br-].[Mg+2].[c-]1ccccc1 |
| InChIKey | ANRQGKOBLBYXFM-UHFFFAOYSA-M |
| PubChem CID | 66852 |
| ChEBI | CHEBI:51238 |
| EC No. | 202-867-2 |
| DTXSID | DTXSID3059214 |
화학 및 물리적 성질
| 극성 표면적 | 0 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 8 |
| 형식 전하 | 0 |
| 복잡도 | 100 |
| 물질 분류 | Metals -> Metals, Organic Compounds |
| 밀도 | 1.14Relative density: 1.134 mg/L at 25 °C1.134 g/mL at 25 °C |
| Color/Form | A solution in etherLiquid |
| Physical Description | 3 molar (76%) solution in diethyl ether: Yellow to brown liquid[Alfa Aesar MSDS] |
| Other Experimental Properties | Substances and mixtures, which In contact with water, emit flammable gases |
| 녹는점 | 153-154 °C |
| 인화점 | −40 °F |
| 저장 조건 | water-free area |
| 용해도 | 테트라히드로푸란과 혼합 가능. |
| 물리적 상태 | 액체 |
| 색상 | 노란색에서 갈색으로 |
| 비중 | 1.14 |
| 용해도 | 물과 반응 |
| BRN | 3588849 |
| InChI | InChI=1S/C6H5.BrH.Mg/c1-2-4-6-5-3-1/h1-5H1H/q+1/p-1 |
| InChIKey | ANRQGKOBLBYXFM-UHFFFAOYSA-M |
| SMILES | C1([Mg]Br)C=CC=CC=1 |
| EPA | Magnesium, bromophenyl- (100-58-3) |
화학적 성질
Clear light brown to brown solution.
안전 및 규제
| GHS 분류 | DangerH225 (39.2%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 74 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | REACH registered substance: Bromophenylmagnesium (EC: 202-867-2)Magnesium, bromophenyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| 화재 가능성 | Dangerous fire risk, solution highly flammable. |
| 유해성 요약 | 3 molar solution in diethyl ether (CAS# 60-29-7): Reacts violently with water evolving flammable gasesMay form explosive peroxidesCauses burns[Alfa Aesar MSDS] See Methyl magnesium bromide, Cyclohexylmagnesium chloride, Phenylmagnesium chloride, and Ethyl magnesium bromide. |
| Hazard Classes and Categories | Flam. Liq. 2 (39.2%) |
| 처리 방법 | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. |
| Protective Action Criteria (PAC) | 1.2 [mg/m3]13 [mg/m3]79 [mg/m3] |
| 유해 작용 | Dermatotoxin - Skin burns. |
| 독성 요약 | IDENTIFICATION AND USE: Phenylmagnesium bromide is used for chemical Synthesis as Grignard reagent. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: There are no data available. |
| Antidote and Emergency Treatment | /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B//SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B//SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/ |
| 수질 위해 등급(WGK) | 1 |
| TSCA 등재 상태 | TSCA listed |
| 운송 번호(UN) | UN 3399 4.3/PG 1 |
| 관세 코드 | 29319090 |
| 위험 문구(R) | 12-14-22-34-19-11-67-40-37 |
| 위험 표시 | F+,C,F |
| 안전 문구(S) | 16-26-36/37/39-45-33-29-7/8-6A-43B |
| 포장분류 | II |
| 위험 등급 | 4.3Acute Tox. 4 OralEye Dam. 1Flam. Liq. 2Skin Corr. 1B |
| F 고인화성물질 | 1-3-10 |
| 저장 분류 | 3 - Flammable liquids |
| 유해 물질 데이터 | 100-58-3(Hazardous Substances Data) |
용도
용도
Phenylmagnesium Bromide is a reagent used in the preparation of arylcarbonimidic dichlorides via dichloroiodobenzene-mediated gem-dichlorination of aryl isonitriles.