Alacepril

HCID 71992CAS 74258-86-9
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기본 정보

표준 SMILES
CC(=O)SC[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
InChIKey
FHHHOYXPRDYHEZ-COXVUDFISA-N
분자식
C20H26N2O5S
평균 분자량
406.5 g/mol
단동위원소 질량
406.15624293

개요

Alacepril is a dipeptide and a thioacetate ester. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor.

이름 및 식별자

우선 이름
Alacepril
IUPAC
(2S)-2-[[(2S)-1-[(2S)-3-acetylsulfanyl-2-methylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

이름 및 동의어

alacepril74258-86-9CetaprilAlaceprilumaraceprilDU-1219DTXSID3048576X39TL7JDPF1-(D-3-Acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanineNSC-338157N-(1-((S)-3-Mercapto-2-methylpropionyl)-L-prolyl)-3-phenyl-L-alanine acetate (ester)DTXCID3028502
이름 더 보기
N-(1-(3-(acetylthio)-2-methyl-1-oxopropyl)-L-prolyl)-L-phenylalanineRefChem:915340(2S)-2-((2S)-1-((2S)-3-(Acetylsulfanyl)-2-methylpropanoyl)pyrrolidine-2-carbonyl)amino-3-phenylpropanoic acidCetapril (TN)DU 12191-[(2s)-3-(acetylsulfanyl)-2-methylpropanoyl]-l-prolyl-l-phenylalanineN-(2-((S)-3-Acetylthio-2-methylpropionyl)propyl)-3-phenylalanin(2S)-2-[[(2S)-1-[(2S)-3-acetylsulfanyl-2-methylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

데이터베이스 식별자

CAS
74258-86-9
PubChem CID
71992
DTXSID
DTXSID3048576
ChEMBL
CHEMBL2103775
ChEBI
CHEBI:31182
UNII
X39TL7JDPF
Nikkaji
J22.086H

물성

구조 계산 물성

XLogP
2.1
극성 표면적
129 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
6
회전 가능 결합 수
9
무거운 원자 수
28

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

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