Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → HCID 11011182, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 반응물 | 2-Hydroxy-4-methyl-3-nitropyridine | HCID 345370 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 11011182 | HCID 11011182 | 56% |
반응 단계
To a stirred suspension of 4-methyl-3-nitro-2-pyridone (2.0 g, 13 mmol) in DMF (60 mL) was added NaH (60% suspension in oil, 0.52 g). After 1 hour, 4-methoxybenzyl chloride (1.8 mL) was added, and the mixture was stirred at rt overnight. Ethyl acetate was added, and the organic phase was washed with water, dried, filtered and evaporated. Chromatography of the residue over silica gel (ethyl acetate/hexane) gave 1-(4-methoxybenzyl)-4-methyl-3-nitro-2-pyridone (2.0 g, 7.3 mmol, 56%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06054470 |
| 출처 데이터셋 | uspto-grants-2000_04 |
| ORD ID | ord-6fe0c71066cb46978ebd0d24c3978065 |
| 출처 메모 | uspto-grants-2000_04 |