Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-indazol-7-amine → 4,5,6,7-tetrahydro-1H-indazol-7-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-indazol-7-amine | HCID 88901 | — |
| 촉매 | Rhodium | HCID 23948 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4,5,6,7-tetrahydro-1H-indazol-7-amine | HCID 21941962 | 28% |
반응 단계
Combine 1H-indazol-7-ylamine (5.0 g, 37.6 mmol) and 5% Rh/C (2.45 g) in ethanol (120 mL) and heat at 120° C. for 48 hours under ˜1000 psi H2. Cool the reaction and filter through hyflo. Remove the solvent in vacuo and purify the crude product with 5% 2 M NH3 in MeOH in CH2Cl2 to afford 1.43 g (28%) of the titled product. MS (m/z): 138 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07981918B2 |
| 출처 데이터셋 | uspto-grants-2011_07 |
| ORD ID | ord-0c2ef847358947b4850acc0bc880c4ca |
| 출처 메모 | uspto-grants-2011_07 |