Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1032542생성일: 2026년 10월 23일
Methanesulfonyl chloride → N-[4-(2-Dimethylaminoethyl)-1H-indazol-7-yl]methanesulfonamide, Hydrochloride
https://huagongshe.com/ko/reaction/1032542
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | N,N-dimethyl-N-[2-(7-amino-1H-indazol-4-yl)ethyl]amine | HCID 13629325 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-[4-(2-Dimethylaminoethyl)-1H-indazol-7-yl]methanesulfonamide, Hydrochloride | HCID 131716572 | — |
반응 단계
At 0° C., 1.2 g of N,N-dimethyl-N-[2-(7-amino-1H-indazol-4-yl)ethyl]amine in 10 ml of dimethylformamide and 5 ml of tetrahydrofuran is combined with 0.91 ml of methanesulfonyl chloride The mixture is agitated for 2 hours at 0° C. and for 14 hours at room temperature. The product is chromatographed on silica gel with methanol/dichloromethane 1:1 and treated with ethereal hydrochloric acid, obtaining, after recrystallization from methanol/diethyl ether, 550 mg of N-[4-(2-dimethylamino-ethyl)-1H-indazol-7-yl]methanesulfonamide, hydrochloride, mp 203°-205° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04958026 |
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| 출처 데이터셋 | uspto-grants-1990_09 |
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| ORD ID | ord-e67e53afb7fe4fdc9e7d4a7a681f1169 |
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| 출처 메모 | uspto-grants-1990_09 |
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