Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethyl orthoformate → 5-({[3-Iodo-4-(methoxy)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethyl orthoformate | HCID 9005 | — |
| 반응물 | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| 반응물 | 3-Iodo-4-methoxyaniline | HCID 22054596 | — |
| 생성물 | 5-({[3-Iodo-4-(methoxy)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 57465576 | 85.9% |
반응 단계
A mixture of 2,2-dimethyl-1,3-dioxane-4,6-dione (203 g, 1.4 mol) and trimethoxymethane (1.51) was heated to reflux for 1 h, then the 3-iodo-4-methoxy-aniline (349.2 g, 1.402mol) was added portionwise. The reaction mixture was stirred at reflux for 1 h, then cooled to room temperature. The resulting precipitate was filtered off, washed with diisopropyl ether and dried to give the title compound as a beige powder (485 g, 85.9%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08557984B2 |
| 출처 데이터셋 | uspto-grants-2013_10 |
| ORD ID | ord-b651989284a04411be9a123ed9508a84 |
| 출처 메모 | uspto-grants-2013_10 |