Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Methyl 2-(benzylamino)-4-fluorobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | Methyl 2-amino-4-fluorobenzoate | HCID 14075433 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 2-(benzylamino)-4-fluorobenzoate | HCID 43735197 | — |
반응 단계
Methyl 2-amino-4-fluorobenzoate (0.90 g), benzaldehyde (0.54 mL), sodium triacetoxyborohydride (1.58 g) and acetic acid (0.3 mL) in CH2Cl2 (20 mL) were stirred for 3 hours. The reaction was quenched with methanol, concentrated, and chromatographed on silica gel with 5% ethyl acetate/hexanes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08563735B2 |
| 출처 데이터셋 | uspto-grants-2013_10 |
| ORD ID | ord-e40a7db9b9394ec0a2ac589f2b56a313 |
| 출처 메모 | uspto-grants-2013_10 |