Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1045504생성일: 2026년 10월 23일
Cesium carbonate → 5-[(3-amino-1-methyl-1H-indazol-6-yl)oxy]-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one
https://huagongshe.com/ko/reaction/1045504
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 5-chloro-3-[(4-methoxyphenyl)methyl]-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-2-one | HCID 66926291 | — |
| 반응물 | 3-amino-1-methyl-1H-indazol-6-ol | HCID 135742460 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-[(3-amino-1-methyl-1H-indazol-6-yl)oxy]-3-(4-methoxybenzyl)-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one | HCID 70497185 | 70.4% |
반응 단계
Suspended 5-chloro-3-(4-methoxy-benzyl)-3,4-dihydro-1h-pyrido[2,3-d]pyrimidin-2-one (400.00 mg; 1.32 mmol; 1.00 eq.), 3-amino-1-methyl-1h-indazol-6-ol (268.61 mg; 1.65 mmol; 1.25 eq.) and cesium carbonate (858.15 mg; 2.63 mmol; 2.00 eq.) in DMF (4.00 ml). Heated in a microwave at 130° C. for 90 min. The reaction was concentrated, redissolved in DMSO (20 mL) and filtered through celite. Purified filtrate via prep HPLC to afford 400 mg (56%) of compound 276 as a tan solid. LC-MS (M+H=431, obsd.=431)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08569295B2 |
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| 출처 데이터셋 | uspto-grants-2013_10 |
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| ORD ID | ord-ca4ffde5bd114f9091d795fa9afd8acc |
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| 출처 메모 | uspto-grants-2013_10 |
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