Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 1-[2-(Tetrahydro-2h-pyranyloxy)ethyl]-4-(5-isoquinolyl)aminopiperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(2-Bromoethoxy)tetrahydro-2H-pyran | HCID 86621 | — |
| 반응물 | 5-Isoquinolinamine, N-4-piperidinyl-, hydrochloride | HCID 11436988 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[2-(Tetrahydro-2h-pyranyloxy)ethyl]-4-(5-isoquinolyl)aminopiperidine | HCID 21979920 | — |
반응 단계
A suspension of the compound of Example 20 (70 mg) and potassium carbonate (142 mg, Kokusan Chemical) in N,N-dimethylformamide (1.5 ml) was added with 2-(2-bromoethoxy)tetrahydro-2H-pyran (254 μl, Aldrich) and stirred at room temperature for 48 hours. The reaction mixture was added with acetone (10 ml), and insoluble matters were separated by filtration. Then, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol=6:1) to obtain the title compound (40 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094789B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-89e65fdcf54141689ca1a566dc61bce4 |
| 출처 메모 | uspto-grants-2006_08 |