Tert-Butylamine → HCID 13178322, 화합물

HRID 1074371

반응식

HRID 1074371 반응식
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8]([S:15](Cl)(=[O:17])=[O:16])=[CH:7]1>O1CCCC1>[C:1]([NH:5][S:15]([C:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:6][CH:7]=1)(=[O:16])=[O:17])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6385Tert-ButylamineHCID 27763401-Benzothiophene-3-sulfonyl chloride

생성물 1

HCID 13178322HCID 13178322, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 25 g of tert-butyl amine in 100 ml of dry tetrahydrofuran was added dropwise with cooling 34 g of benzothiophene-3-sulfonyl chloride. The reaction mixture was allowed to come to room temperature and then poured into 200 g of ice. The phases were separated and the organic portion was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue thus obtained melted at 146°-148° after recrystallization from alcohol. It showed an absorption peak by NMR at 1.34 δ (singlet), for tert-butyl and 7.4-8.4 δ (multiplet) for benzothiophene consistent for the desired product.

후처리

  1. customto come to room temperature
  2. customThe phases were separated
  3. washthe organic portion was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo
  6. customThe residue thus obtained melted at 146°-148° after recrystallization from alcohol

출처 및 근거

ORD 기록
ord-c5dc0a21952943dbae1a78ce65def847
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04391627

연결된 노트

불러오는 중…