Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 2',5'-Dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Thiopheneacetyl chloride | HCID 162362 | — |
| 반응물 | 5'-Amino-2',5'-dideoxy-5-ethyluridine | HCID 451828 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2',5'-Dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine | HCID 54570891 | 52.8% |
반응 단계
0.18 g of 2-thiopheneacetylchloride was added to a solution of 0.255 g of 5'-amino-2',5'-dideoxy-5-ethyluridine in 5 ml of water containing 1.2 ml of 1M sodium hydroxide solution and the resulting mixture was shaken vigorously for 10 minutes. The resulting white solid was collected by filtration, washed with water, dried at 50° C. in vacuo over phosphorus pentoxide and recrystallized from ethanol to give 0.2 g of 2',5'-dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine of melting point 215°-217° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05010060 |
| 출처 데이터셋 | uspto-grants-1991_04 |
| ORD ID | ord-4793037ff7474d6dbdda4aa7fcbe1ce1 |
| 출처 메모 | uspto-grants-1991_04 |