Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Hydroxybenzotriazole → N-(Morpholinocarbonyl)-L-phenylalanine S-methyl-L-cysteine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | CP 84364 | HCID 664657 | — |
| 반응물 | Methyl (2R)-2-amino-3-(methylsulfanyl)propanoate | HCID 1277655 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(Morpholinocarbonyl)-L-phenylalanine S-methyl-L-cysteine methyl ester | HCID 67865905 | 78% |
반응 단계
To a solution of 0.96 g N-(morpholinocarbonyl)-L-phenylalanine 3 and 0.55 g S-methyl-L-cysteine methyl ester in 50 mL anhydrous methylene chloride at ambient temperature was added 0.50 mL triethylamine, 0.51 g 1-hydroxybenzotriazole and 0.70 g 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride. After being stirred for 4 h, the solution was diluted with 100 mL ethyl acetate and was washed with 2×35 mL 0.1N hydrochloric acid solution and 2×35 mL 0.1N sodium hydroxide solution. The organic phase was dried over magnesium sulfate, filtered and concentrated in vacuo to afford 1.15 g of the desired solid dipeptide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05034376 |
| 출처 데이터셋 | uspto-grants-1991_07 |
| ORD ID | ord-9f93c1358bdf4432a0b26833ddc82d78 |
| 출처 메모 | uspto-grants-1991_07 |