Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitroethane → 3-Nitro-1-phenoxy-butan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitroethane | HCID 6587 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Phenoxyacetaldehyde | HCID 75033 | — |
| 반응물 | 2,8,9-Triisopropyl-2,5,8,9-tetraaza-1-phosphabicyclo[3,3,3]undecane | HCID 5148322 | — |
| 용매 | Nitromethane | HCID 6375 | — |
| 생성물 | 3-Nitro-1-phenoxy-butan-2-ol | HCID 15105308 | 81% |
반응 단계
2-Phenoxyacetaldehyde (1.36 g, 10 mmol) was added to a suspension of anhydrous magnesium sulfate (2.65 g, 22 mmol) in nitroethane (7.0 mL) under an argon atmosphere. After 5 min a solution of 2,8,9-triisopropyl-2,5,8,9-tetraaza-1-phosphabicyclo[3,3,3]undecane (0.30 g, 1.0 mmol) in nitromethane (3.0 mL) was added. The mixture was vigorously stirred for 5 days at r.t., filtered through celite and concentrated. Purification by column chromatography (SiO2, dichloromethane/t-butyl methyl ether) gave the subtitle compound as an oil (1.7 g, 81%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08143290B2 |
| 출처 데이터셋 | uspto-grants-2012_03 |
| ORD ID | ord-957d13106596469fb007a8b54135da77 |
| 출처 메모 | uspto-grants-2012_03 |