2-Iodohexane → HCID 22923697, 화합물

HRID 1107565

반응식

HRID 1107565 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.I[CH:9]([CH2:11][CH2:12][CH2:13][CH3:14])[CH3:10]>CC(CC)=O>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:10][CH2:9][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 330192-IodohexaneHCID 79341Piperidin-4-ol

생성물 1

HCID 22923697HCID 22923697, 화합물수율 64%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

4-Hydroxypiperidine (2.02 g, 20 mmol) was dissolved in 100 mL of methyl ethylketone. To this stirred mixture was added 2-iodohexane (1.5 mL, 10 mmol) and the resulting solution was heated at reflux for 1.5 hours. The mixture was allowed to cool and was then washed with saturated aqueous sodium bicarbonate (3×75 mL). The organic layer was dried over magnesium sulfate, filtered, and evaporated, and the residue was dried overnight under house vacuum to yield 1.184 g (64%) of the title compound which was used without further purification. 1H NMR consistent with desired product. MS(FD) 186(M+).

후처리

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for 1.5 hours
  3. temperatureto cool
  4. washwas then washed with saturated aqueous sodium bicarbonate (3×75 mL)
  5. dry with materialThe organic layer was dried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated
  8. customthe residue was dried overnight under house vacuum

출처 및 근거

ORD 기록
ord-e3f26c66634643b08fe45bb101c390a3
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060488

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