Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trityl chloride → Bifonazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trityl chloride | HCID 6456 | — |
| 반응물 | 4-(Chlorophenylmethyl)-1,1'-biphenyl | HCID 111006 | — |
| 반응물 | TMS-Imidazole | HCID 14420972 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Bifonazole | HCID 2378 | 52.1% |
반응 단계
167 g (0.6 mol) of biphenyl-4-yl-phenyl-chloromethane [alternatively named as diphenyl-phenyl-chloromethane or as α-(biphenyl-4-yl)benzyl chloride] and 92 g (0.66 mol) of trimethylsilylimidazole, dissolved in 500 ml of acetonitrile, are heated under reflux for 15 hours. After distilling off the solvent, the crystalline residue is purified by recrystallization from ethyl acetate. 97 g (52% of theory) of (biphenyl-4-yl)-imidazol-1-yl-phenylmethane of melting point 142° C. are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04118487 |
| 출처 데이터셋 | uspto-grants-1978_10 |
| ORD ID | ord-5bffc8abda5f4c0ba78b60f58d66befa |
| 출처 메모 | uspto-grants-1978_10 |