Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4'-ethyl-3'-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| 반응물 | 1-Ethyl-2-methylpiperazine | HCID 17750365 | — |
| 생성물 | 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4'-ethyl-3'-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid | HCID 10109876 | 51% |
반응 단계
The condensation of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 4-ethyl-3-methylpiperazine was carried out in a similar manner as described in example 1 gave the titled product. Yield 51%, m.p 200° C., C20H24FN3O3, m/z 374 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098219B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-f878f40338784547baf46f135f7a5b94 |
| 출처 메모 | uspto-grants-2006_08 |