Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 113생성일: 2026년 10월 23일
3-(2,5-Dichloropyrimidin-4-yl)imidazo[1,2-a]pyridine → 1-[4-[4-[(5-Chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-2,5-dimethoxyphenyl]piperazin-1-yl]ethanone
https://huagongshe.com/ko/reaction/113
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(2,5-Dichloropyrimidin-4-yl)imidazo[1,2-a]pyridine | HCID 46934605 | — |
| 반응물 | 1-(4-(4-Amino-2,5-dimethoxyphenyl)piperazin-1-yl)ethanone | HCID 68592415 | — |
| 시약 | Cesium carbonate | HCID 10796 | — |
| 촉매 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-[4-[4-[(5-Chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-2,5-dimethoxyphenyl]piperazin-1-yl]ethanone | HCID 45381988 | 0% |
반응 단계
_3-(2,5-dichloropyrimidin-4-yl)imidazo[1,2-a]pyridine (132.5 mg, 0.50 mmol)_ _ _ _1-(4-(4-amino-2,5-dimethoxyphenyl)piperazin-1-yl)ethanone (140 mg, 0.50 mmol)_ ___(9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (23.14 mg, 0.04 mmol)_ _ _ _cesium carbonate (244 mg, 0.75 mmol)_ ___diacetoxypalladium (4.49 mg, 0.02 mmol)_ _were suspended in_ _1,4-dioxane (4 ml)_ _,degased with argon . The mixture was heated to_ _80 °C_ _ for 2 hrs *_
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-ea73803169b640e3b40a2b6127b91b44 |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
