참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Ethyl 2-pyridylacetate | HCID 75960 | — |
| 반응물 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 3-(dimethylamino)-2-(2-pyridinyl)-2-propenoate | HCID 73047442 | — |
반응 단계
10 g of ethyl 2-(2-pyridinyl)acetate, 39 ml of dimethoxy-N,N-dimethylmethanamine and 1.5 ml of N,N,N′,N′-tetramethylenediamine are mixed and the mixture is heated at 130° C. for 18 hours. The mixture is taken up in 120 ml of a mixture of equal volumes of AcOEt and of a saturated NH4Cl solution. The organic phase is separated by settling, washed with a saturated NaCl solution, dried over Na2SO4 and evaporated to produce the expected product in the form of an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07816368B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_10 |
|---|
| ORD ID | ord-1653dbe7e59742519c502e2e7620dcb8 |
|---|
| 출처 메모 | uspto-grants-2010_10 |
|---|
