Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Benzyl 3-oxocyclopentanecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Oxocyclopentanecarboxylic acid | HCID 227798 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Benzyl 3-oxocyclopentanecarboxylate | HCID 14530748 | — |
반응 단계
To a solution of 3-carboxycyclopentanone (640 mg, 5.0 mmol) in 8 mL of degassed DMF was added potassium carbonate (828 mg, 5.99 mmol) and benzyl bromide (0.65 mL, 5.49 mmol). After 4 hours at room temperature, the reaction mixture was poured into 50 mL of water and extracted 3 times with EtOAc. The combined organic layers were washed with water and dried over sodium sulfate. Filtration and solvent removal provided material that was subjected to silica gel chromatography eluting with 10% EtOAc in hexanes to yield benzyl 3-oxocyclopentanecarboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07816380B2 |
| 출처 데이터셋 | uspto-grants-2010_10 |
| ORD ID | ord-850faf859de6495bbc7ecf00d17421a9 |
| 출처 메모 | uspto-grants-2010_10 |