Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → Ethyl 6-(bromomethyl)picolinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | Ethyl 6-methylpyridine-2-carboxylate | HCID 564597 | — |
| 촉매 | Benzoyl Peroxide | HCID 7187 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | Ethyl 6-(bromomethyl)picolinate | HCID 23033755 | 98.3% |
반응 단계
A mixture of 6-methyl-pyridine-2-carboxylic acid ethyl ester (1.65 g, 10 mmol), NBS (1.77 g, 10 mmol), and benzoyl peroxide (100 mg) in carbon tetrachloride (20 ml) was refluxed for 14 h. After cooling to room temperature, the reaction mixture was partitioned between diethyl ether and water (120 ml, 4:1), organic layer was washed with water (2×20 ml), brine, dried (MgSO4), filtered and concentrated to give 6-bromomethyl-pyridine-2-carboxylic acid ethyl ester (2.4 g) which was used without further purification. LCMS m/z: 245 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07820704B2 |
| 출처 데이터셋 | uspto-grants-2010_10 |
| ORD ID | ord-68468710087740078ac5874558b61ab5 |
| 출처 메모 | uspto-grants-2010_10 |