Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → alpha-(Aminomethyl)-4-methoxybenzyl alcohol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | 4-Methoxybenzaldehyde | HCID 31244 | — |
| 반응물 | Fumaric Acid | HCID 444972 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 생성물 | alpha-(Aminomethyl)-4-methoxybenzyl alcohol | HCID 3016949 | — |
반응 단계
2-Amino-1-(4-methoxyphenyl)ethanol was prepared according to the procedure of Evans et al., J. Org. Chem., 39, 914 (1974) by cyanosilylation of 4-methoxybenzaldehyde followed by lithium aluminum hydride reduction. The crude aminoalcohol (36.9 g) was dissolved in 150 mL of hot ethanol on a steam bath. To this mixture was slowly added 12.83 g of fumaric acid. The precipitated salt was filtered and washed with additional ethanol. Recrystallization from methanol provided greater than 99% pure 2:1 amine:fumarate salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07820785B2 |
| 출처 데이터셋 | uspto-grants-2010_10 |
| ORD ID | ord-4f214d5ffe7b408ba41ae7cf9e3a8882 |
| 출처 메모 | uspto-grants-2010_10 |