Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triacetoxyperiodinane → 3-(3-Quinolinyl)-2-propynal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | 3-Quinolin-3-ylprop-2-yn-1-ol | HCID 650142 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(3-Quinolinyl)-2-propynal | HCID 22630772 | 72.6% |
반응 단계
A mixture of 3-(3-quinolinyl)-2-propyn-1-ol (prepared as described in J. Med Chem. 1996, 39, 3179) (360 mg, 1.96 mmol) and the Dess-Martin reagent (1.00 g, 2.36 mmol) in dichloromethane (10 mL) was stirred at RT for 1.5 h. The solution was washed with sat. aq. NaHCO3 and brine, dried (MgSO4), and concentrated. Purification by chromatography (SiO2, 1:4 hexane/ethyl acetate) yielded 258 mg (72%) of the title compound. MS 182 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06613747B2 |
| 출처 데이터셋 | uspto-grants-2003_09 |
| ORD ID | ord-64cd140bd5b64aae8b288f6161cea79c |
| 출처 메모 | uspto-grants-2003_09 |