Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrrolidine → (E)-3-{[2-(t-butoxycarbonylamino)-1,3-thiazol-4-yl]methylidene}-1-(triphenylmethyl)piperidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 1-Tritylpiperidin-4-one | HCID 2748414 | — |
| 반응물 | (4-Formylthiazol-2-yl)carbamic acid tert-butyl ester | HCID 23138686 | — |
| 생성물 | (E)-3-{[2-(t-butoxycarbonylamino)-1,3-thiazol-4-yl]methylidene}-1-(triphenylmethyl)piperidin-4-one | HCID 23138600 | 36.2% |
반응 단계
Following a procedure similar to that described in Example 132-(c), 2-(t-butoxycarbonylamino)-1,3-thiazole-4-carbaldehyde (3.2 g) was subjected to the reaction with 1-(triphenylmethyl)piperidin-4-one (4.8 g) and pyrrolidine (0.24 ml), and the crude product was purified by silica gel chromatography using hexane, ethyl acetate, and dichloromethane (1:3:1 to 1:5:1) as eluents to afford the title compound (2.8 g, yield: 36%) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07829580B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-c5ad84445c954988a7a6dc4cfa4c3ba9 |
| 출처 메모 | uspto-grants-2010_11 |