참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Succinic Acid | HCID 1110 | — |
| 반응물 | Solifenacin | HCID 154059 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Solifenacin Succinate | HCID 216457 | — |
반응 단계
The thus obtained solifenacin was mixed with 12 ml of EtOH, 28 ml of EtOAc and 2.74 g of succinic acid, heated, cooled to 30° C. and then again heated to 50° C. This was kept at 50° C. for 2 hours and then cooled to 0° C. spending 5 hours, and the precipitated crystals were collected by filtration, washed twice with 8 ml of EtOAc and then dried under a reduced pressure to obtain 9.013 g of solifenacin succinate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07829715B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_11 |
|---|
| ORD ID | ord-b008daffcd744614946eb1f37250dec3 |
|---|
| 출처 메모 | uspto-grants-2010_11 |
|---|
