Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanuric chloride → 4-Chlorothieno[2,3-b]pyridine-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanuric chloride | HCID 7954 | — |
| 반응물 | 4-Chlorothieno[2,3-B]pyridine-5-carboxamide | HCID 11148561 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Chlorothieno[2,3-b]pyridine-5-carbonitrile | HCID 11412907 | 63.5% |
반응 단계
A mixture of 4-chlorothieno[2,3-b]pyridine-5-carboxamide (145 mg, 0.68 mmol) and cyanuric chloride (200 mg, 1.08 mmol) in 5 mL of N,N-dimethylformamide is stirred at room temperature for 30 minutes. Ice is added to the reaction mixture and the resultant solids are collected by filtration washing with water to provide 84 mg of 4-chlorothieno[2,3-b]pyridine-5-carbonitrile as a white solid, mp 100–103° C.; 1H NMR (DMSO-d6) δ 7.66 (d, J=6 Hz, 1H), 8.26 (d, J=6 Hz, 1H), 9.03 (s, 1H); MS 195.0 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07276519B2 |
| 출처 데이터셋 | uspto-grants-2007_10 |
| ORD ID | ord-68cbe3a5969d4df98e87fabf9a0fb916 |
| 출처 메모 | uspto-grants-2007_10 |