Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Candesartan Cilexetil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Trityl candesartan cilexetil | HCID 11029254 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Candesartan Cilexetil | HCID 2540 | — |
반응 단계
A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), methanol (200 ml), and water (1 ml) was gently refluxed for about 16–17 h. The reaction progress was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C. to obtain viscous oil of candesartan cilexetil as a residue.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098342B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-058db254e82c45b7899abb07338a96ad |
| 출처 메모 | uspto-grants-2006_08 |