Nitric Acid → 5-Nitroisoquinoline-1-carboxylic acid

HRID 1181428

반응식

HRID 1181428 반응식
[C:1]1([C:11]([OH:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[N+:14]([O-])([OH:16])=[O:15]>S(=O)(=O)(O)O>[N+:14]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:5]=1[CH:4]=[CH:3][N:2]=[C:1]2[C:11]([OH:13])=[O:12])([O-:16])=[O:15]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 68092Isoquinoline-1-carboxylic acid

생성물 1

HCID 2856465-Nitroisoquinoline-1-carboxylic acid수율 82%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

반응 조건

온도
0 °C

실험 절차

Isoquinoline-1-carboxylic acid (3.98 g, 23.0 mmol) was dissolved in conc. sulfuric acid (16 ml) at 0° C. A mixture of conc. sulfuric acid (5 ml) and fuming nitric acid (5 ml) was added over 10 min. and the reaction stirred for a further 1 h at 0° C., then poured into ice-water (400 ml). The solid was collected by filtration, then washed with water (100 ml), ethanol (100 ml) and ether (100 ml), then dried under vacuum to give the title compound (4.1 g, 82%).

후처리

  1. additionwas added over 10 min.
  2. filtrationThe solid was collected by filtration
  3. washwashed with water (100 ml), ethanol (100 ml) and ether (100 ml)
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-5a14113c17d045dfa70c11d5175d45d3
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285563B2

연결된 노트

불러오는 중…