(Trifluoromethyl)trimethylsilane → HCID 67401736, 화합물

HRID 1186356

반응식

HRID 1186356 반응식
[N:1]1([C:6]2[N:11]=[CH:10][C:9]([CH:12]=[O:13])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:14][C:15]([Si](C)(C)C)([F:17])[F:16].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([CH:12]([OH:13])[C:15]([F:17])([F:16])[F:14])=[CH:10][N:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 552549(Trifluoromethyl)trimethylsilaneHCID 2724141Tetrabutylammonium FluorideHCID 27947756-(Pyrrolidin-1-yl)pyridine-3-carbaldehyde

생성물 1

HCID 67401736HCID 67401736, 화합물수율 94%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

According to Reference Example 8-12, by use of 6-(pyrrolidin-1-yl)-3-pyridinecarboxaldehyde (173 mg, 0.982 mmol), (trifluoromethyl)trimethylsilane (174 μL, 1.18 mmol), tetrabutylammonium fluoride (a 1.0 mol/L solution in tetrahydrofuran, 98.0 μL, 0.098 mmol) and tetrahydrofuran (5.0 mL), the mixture was stirred and reacted at room temperature for 30 minutes. Then, slurry purification was performed using hexane, to give 2-(pyrrolidin-1-yl)-5-(2,2,2-trifluoro-1-hydroxyethyl)-pyridine (Compound DH) (227 mg, yield: 94%).

후처리

  1. customreacted at room temperature for 30 minutes
  2. customThen, slurry purification

출처 및 근거

ORD 기록
ord-fd9eef4168e448158e86ec565aff527f
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673908B2

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