Thionyl Chloride → HCID 86659460, 화합물

HRID 1256633

반응식

HRID 1256633 반응식
[ClH:1].[N:2]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=2)[C:11](O)=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3]1.S(Cl)([Cl:19])=O>O1CCCC1>[ClH:19].[N:2]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=2)[C:11]([Cl:1])=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 185258743-[(Pyrrolidin-1-yl)methyl]benzoic acid hydrochloride

생성물 1

HCID 86659460HCID 86659460, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A suspension of 3-pyrrolidin-1-ylmethyl-benzoic acid hydrochloride (850 mg, 3.5 mmol) in dry tetrahydrofuran was treated with 2.55 mL of thionyl chloride (35 mmol, 10 eq) and stirred at room temperature for 2 hours. The solution thus obtained was then evaporated to dryness, the residue suspended in dry toluene, evaporated to dryness and dried under vacuum affording the title compound as pale brown solid (quantitative).

후처리

  1. customThe solution thus obtained
  2. customwas then evaporated to dryness
  3. customevaporated to dryness
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-f80cf0c6d3fd4e84802ff117c8cf085f
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461193B2

연결된 노트

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