Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → diethyl O-[4-(2-cyclohexylethylamino)phenylacetyl]tartrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Butanedioic acid, 2,3-dihydroxy-, diethyl ester, S-(R*,R*)- | HCID 62333 | — |
| 반응물 | 4-[N-trifluoroacetyl-(2-cyclohexylethylamino)]phenylacetyl chloride | HCID 20499025 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | diethyl O-[4-(2-cyclohexylethylamino)phenylacetyl]tartrate | HCID 20498970 | — |
반응 단계
A mixture of 4-[N-trifluoroacetyl-(2-cyclohexylethylamino)]phenylacetyl chloride and 1.2 g. triethylamine in 100 ml. warm ether is treated with 2.5 g. diethyl tartrate and refluxed for 24 hours. The hot solution is filtered, the residue is washed with hot ether, and the solution is evaporated. After treatment with aqueous methanolic potassium carbonate, the product is precipitated by acidification, filtered, and dried. Crystallization from acetone yields diethyl O-[4-(2-cyclohexylethylamino)phenylacetyl]-tartrate as a white, crystalline solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04259352 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-d6bcb04ee69c4d97b29d544f194fa0b0 |
| 출처 메모 | uspto-grants-1981_03 |