Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanolamine → 5-(2-Hydroxy-ethylamino)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013543 | — |
| 생성물 | 5-(2-Hydroxy-ethylamino)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013859 | — |
반응 단계
Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 59 mg; 0.20 mmol) and ethanolamine (0.20 mL; 3.3 mmol) under microwave irradiation according to the procedure described in Example 14 Step 2 provided after purification by reverse phase HPLC, 5-(2-hydroxy-ethylamino)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (26 mg, 41%) as a white powder. ES-HRMS m/e calcd for C17H27N4O2 (M+H+) 319.2129, found 319.2127.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728029B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-30b533f8974244a4b07fda87e628beb1 |
| 출처 메모 | uspto-grants-2010_06 |