Sodium Acetate → HCID 2910222, 화합물

HRID 1289158

반응식

HRID 1289158 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=1.C([O-])(=O)C.[Na+].[S:24]1[CH2:30][C:28](=[O:29])[NH:27][C:25]1=[S:26]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[C:30]2[S:24][C:25](=[S:26])[NH:27][C:28]2=[O:29])=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 7354674-[(2-Chloro-6-fluorophenyl)methoxy]benzaldehydeHCID 1201546Rhodanine

생성물 1

HCID 2910222HCID 2910222, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Under a nitrogen atmosphere in a round bottom flask 4-[(2-chloro-6-fluorophenyl)methoxy]benzaldehyde (1.00 g, 3.78 mmol) was dissolved in acetic acid (19 ml). To this solution was added sodium acetate (1.08 g, 13.2 mmol) and then rhodanine (0.50 g, 3.75 mmol). The reaction mixture was then heated to reflux and maintained at this temeprature. The progress of the reaction was monitored by thin layer chromatography.

후처리

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux
  3. temperaturemaintained at this temeprature

출처 및 근거

ORD 기록
ord-093ea1f308e842fbb0137430c1943964
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747517

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