Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Indole-5-carbonitrile | HCID 27513 | — |
| 반응물 | 1-Methyl-4-piperidone | HCID 74049 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile | HCID 14973216 | 97.6% |
반응 단계
5-Cyanoindole (Aldrich, 20.0 g) was added to a solution of KOH (22.4 g) in methanol (200 ml). N-Methyl-4-piperidone (Aldrich, 40.4 g) was then added dropwise and the resulting mixture refluxed for 4 hours, then cooled and poured into water. The resulting precipitate was filtered off and dried to give the desired product as a pale pink crystalline solid (32.6 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05466699 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-928466b98a0c49e2bfc4209e9e3c633b |
| 출처 메모 | uspto-grants-1995_11 |