Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nabumetone → 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nabumetone | HCID 4409 | — |
| 반응물 | 1-(5-Bromo-6-methoxynaphthalen-2-yl)ethan-1-one | HCID 622178 | — |
| 생성물 | 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one | HCID 70179405 | — |
반응 단계
New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05750793 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-37bfe041c442425998114372078aa3dc |
| 출처 메모 | uspto-grants-1998_05 |