Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-Bromomethylsaccharin | HCID 15225519 | — |
| 반응물 | Methyltriazabicyclodecene | HCID 77320394 | — |
| 반응물 | 2-Hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one | HCID 135758979 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin | HCID 10763054 | 65% |
반응 단계
To a mixture of 2-hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one (0.324 g), and methyltriazabicyclodecene (0.24 mL) in DMF (15 mL) was added 2-bromomethylsaccharin (0.414 g). The mixture was stirred overnight, poured into water and the precipitate which formed was collected by filtration and recrystallized from DMF to afford 0.371 g (65%) of 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05466701 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-bdefed0c38144a238c0018a84a3d9e58 |
| 출처 메모 | uspto-grants-1995_11 |