Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → HCID 70290042, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Acetaldehyde, bromo- | HCID 105131 | — |
| 반응물 | 1-(2-Amino-1-ethyl)-4-(1,4-benzodioxan-5-yl)piperazine | HCID 10587641 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethylacetate methanol | HCID 21584119 | — |
| 생성물 | HCID 70290042 | HCID 70290042 | — |
반응 단계
A mixture of 1-(2-amino-1-ethyl)-4-(1,4-benzodioxan-5-yl)piperazine (9.1 g), bromoacetaldehyde dimethylacetale (6.5 g), potassium iodide (0.5 g), and potassium carbonate (4.8 g) in 1,4-dioxan (200 ml) was refluxed for 16 h. Water was added followed by extraction with ethyl acetate. The organic phase was concentrated in vacuo leaving an oil which was applied to a silica gel column (eluent: ethyl acetate/methanol=1:3). The product, 1-(1,4-benzodioxan-5-yl)-4-[2-(2,2-dimethoxy-1-ethylamino)-1-ethyl]piperazine, was obtained as an oil (4.7 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753661 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-0e54196d5bb04784812c649f9f2866f4 |
| 출처 메모 | uspto-grants-1998_05 |