참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 3-Pyrrolidinol, 1-(phenylmethyl)-, 3-methanesulfonate, (3R)- | HCID 11807254 | — |
| 촉매 | Tetrabutylammonium Cyanide | HCID 165872 | — |
| 생성물 | (S)-1-Benzyl-pyrrolidine-3-carbonitrile | HCID 1515498 | 85% |
반응 단계
(R)-1-Benzyl-3-mesyloxypyrrolidine (5.0 g, 20 mmol) was dissolved in acetonitrile (6 mL) and tetrabutylammonium cyanide (11.1 g, 41.4 mmol) was added. The mixture was heated at 65° C. for 3 hours and then cooled to room temperature and extracted with ethyl ether (100 mL). The organic layer was washed with saturated NaHCO3 (2×50 mL), dried over MgSO4, and concentrated under reduced pressure to give (S)-1-benzyl-3-cyanopyrrolidine (3.1 g, 85%) as a yellow oil: VPC: 100%;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05466828 |
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| 출처 데이터셋 | uspto-grants-1995_11 |
|---|
| ORD ID | ord-775f15c9248a45b3941a409cfadd43f9 |
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| 출처 메모 | uspto-grants-1995_11 |
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