참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nimesulide | HCID 4495 | — |
| 반응물 | L-Lysine | HCID 5962 | — |
| 반응물 | beta-Cyclodextrin | HCID 444041 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 131720675 | HCID 131720675 | — |
반응 단계
6.16 g of nimesulide (2×10-2 mole) are suspended in 200 ml of distilled water to which 6.56 g of L-lysine (4×10-2 mole) are added. The suspension is subjected to ultrasound for 5 minutes and then heated to 50° C. while violent agitation is maintained [Ultraturrax (registered mark)]. 26.3 g of β-CD·10H2O (2×10-2 mole) are dispersed in 200 ml of distilled water and heated to 50° C. The suspension of β-CD is added to the suspension of nimesulide and L-lysine. The agitation is continued for 15 minutes. An orangy solution is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05756546 |
|---|
| 출처 데이터셋 | uspto-grants-1998_05 |
|---|
| ORD ID | ord-bf87b3b19c2d42b5a53b4db108ba8a26 |
|---|
| 출처 메모 | uspto-grants-1998_05 |
|---|
