Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Guaiacol → 2-Methoxyphenyl chloroformate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Guaiacol | HCID 460 | — |
| 반응물 | N,N-Dimethylaniline | HCID 949 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Phosgene | HCID 6371 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | 2-Methoxyphenyl chloroformate | HCID 3362143 | 50% |
반응 단계
A solution of 2-methoxyphenol (2 g, 16.1 mmol), N,N-dimethylaniline (1.95 g, 16.1 mmol), phosgene (8.34 mL of a 1.93 M solution in toluene, 16.1 mmol) and a catalytic amount of DMF in chlorobenzene (5 mL) was stirred in a pressure tube for 2 h at 80° C. The organic layer was separated and concentrated in vacuo. The residue was distilled (Buchi Kugelrohr; bp=115° C. @ 10 mm Hg) to provide 2-methoxyphenyl chloroformate (1.5 g; 50%) as a clear oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07241780B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-8b70f924843343cab6edbe3c5be4eba6 |
| 출처 메모 | uspto-grants-2007_07 |